Identification of helicobacter pylori infection in patients with upper gastrointestinal diseases, and ITS antimicrobial sensitivity

Abstract EN

H.pylori is the cause of duodenal ulcer, and a lot of other gastrointestinal diseases, the aim of this study was to see the extent of this microorganism in our patients and to study its antimicrobial sensitivity.

The study included 283 patients(148 males and 135 females) with upper gastrointestinal complaints including dyspepsia, heartburn, bleeding, and malabsorption to evaluate the presence of Helicobacter pylori (H.pylori) infection using rapid urease test (RUT) and culture to see there sensitivity to different antibiotics.

The study revealed that 199 patients (70.3 %) have positive RUT compared to 218 patients (77.0 %) showed positive culture results.

The positive culture results were confirmed by positive results of biochemical tests (oxidase, catalase and urease).

Antibiotic sensitivity testing was performed in 28 cultures of H.

pylori, and the results showed that 26 cultures (92.9 %) were sensitive to amoxycillin, followed by clarithromycin, rifampicin and cephalexin with figures of 23 (82.1 %), 22 (78.6 %) and 21 (75.0 %) respectively.

Whereas, 16 cultures (57.1 %) were resistant to metronidazole, 15 (53.4 %) to erythromycin and 9 (32.1 %) to both cephalothin and tetracycline.

It is concluded that, H.pylori infection is a predominant etiological factor of upper gastrointestinal diseases, Also, RUT represent simple, convenient and reliable mean for the rapid diagnosis of H.Pylori infection.

Antibiotic sensitivity was the highest with amoxycillin and clarithromycin while the most resistant antibiotic strains were encountered with metronidazole.