Frequency of cholelithiasis in patients with beta-thalassemia intermedia with and without hydroxyurea

Joint Authors

Karimi, Mahran
Haghpanah, Suzan
Bardestani, Mardih
Khavari, Maryam
Hamidi, Azin
Bagheri, Muhammad Hadi
Hantooshzadeh, Razih

Source

Iranian Red Crescent Medical Journal

Issue

Vol. 16, Issue 7 (31 Jul. 2014), pp.1-5, 5 p.

Publisher

Iranian Hospital

Publication Date

2014-07-31

Country of Publication

United Arab Emirates

No. of Pages

5

Main Subjects

Medicine

Topics

Abstract EN

Background : Recent studies regarding the effect of hydroxyurea (HU) in thalassemia have revealed favorable effects on the reduction of ineffective erythropoiesis.

Objectives : The aim of the current study was to evaluate whether or not HU can have an effect on the gallstone formation rate in patients with beta-thalassemia intermedia (BTI).

Patients and Methods : In this case control cross-sectional study, from a total of 250 transfusion-independent BTI patients, 51 patients who were taking HU, participated in the study.

Patients were registered in the Thalassemia clinic of Shiraz University of Medical Sciences, Shiraz, which is a referral center located in southern Iran, during 2011-2012.

Mean dose of HU consumption in the case group was 10 ± 2.5 mg / kg / day (range of 8-15 mg / kg / day), with a mean duration of consumption of 7.5 ± 3.8 years (range 1-14 years).

In addition, 41 age- and sex-matched BTI patients who did not use HU were randomly selected as a control group.

All patients underwent abdominal ultrasound by a radiologist for evaluation of gallstones.

Results : Mean age of the participants was 21.4 ± 6.5 years (10-40 years).

There was no statistically significant difference regarding the frequency of cholelithiasis between the two groups of patients (P = 0.822).

Our study showed significantly lower hemoglobin levels and a higher percentage of nucleated red blood cells in the HU group compared with the control group (P = 0.001 and P = 0.005, respectively).

Conclusions : It seems that taking HU for long periods can reduce hemolysis and bone marrow suppression, and that decreases the rate of cholelithiasis.

We believe that if these patients had not been treated with HU, we would probably have observed a significantly higher frequency of cholelithiasis, due to more hemolysis compared with patients not taking HU.

Further studies with larger sample sizes are suggested.

American Psychological Association (APA)

Khavari, Maryam& Hamidi, Azin& Haghpanah, Suzan& Bagheri, Muhammad Hadi& Bardestani, Mardih& Hantooshzadeh, Razih…[et al.]. 2014. Frequency of cholelithiasis in patients with beta-thalassemia intermedia with and without hydroxyurea. Iranian Red Crescent Medical Journal،Vol. 16, no. 7, pp.1-5.
https://search.emarefa.net/detail/BIM-387369

Modern Language Association (MLA)

Khavari, Maryam…[et al.]. Frequency of cholelithiasis in patients with beta-thalassemia intermedia with and without hydroxyurea. Iranian Red Crescent Medical Journal Vol. 16, no. 7 (Jul. 2014), pp.1-5.
https://search.emarefa.net/detail/BIM-387369

American Medical Association (AMA)

Khavari, Maryam& Hamidi, Azin& Haghpanah, Suzan& Bagheri, Muhammad Hadi& Bardestani, Mardih& Hantooshzadeh, Razih…[et al.]. Frequency of cholelithiasis in patients with beta-thalassemia intermedia with and without hydroxyurea. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 7, pp.1-5.
https://search.emarefa.net/detail/BIM-387369

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 4-5

Record ID

BIM-387369