Acute interstitial nephritis induced by intermittent use of rifampicin in patient with Burcellosis

Abstract EN

Acute oliguric renal failure (ARF) developed in a patient 2 days after she was started on intermittent anti-Brucella therapy including rifampicin.

The clinical picture was compatible with acute allergic interstitial nephritis.

Renal histology revealed mainly acute tubular necrosis with mild tubulo-intertitial mononuclear cellular infiltrate.

Intermittent therapy, as in our patient, has been the major factor in the development of rifampicin induced ARF in cases reviewed in literature.