Methylenetetrahydrofolate reductase C677T and a1298C polymorphism in Iranian women with idiopathic recurrent pregnancy losses
Joint Authors
Yusufian, Ilham
Kardi, Muhammad Taqi
al-Hafizi, Azra
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 7 (31 Jul. 2014), pp.1-4, 4 p.
Publisher
Publication Date
2014-07-31
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : Recurrent pregnancy loss (RPL) is a serious problem for pregnancy.
There is evidence that vascular complications play a principal role in RPL.
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism.
Polymorphisms (C677T, A1298C) of MTHFR gene are associated with decreased MTHFR activity.
Objectives : The aim of this study was to determine the association between MTHFR polymorphisms (C677T and A1298C) and recurrent pregnancy loss (RPL) in Iranian women.
Materials and Methods : In this case-control study, blood samples were obtained from patients who had three or more consecutive pregnancy losses before the 22nd week of pregnancy (n = 204).
The control group consisted of 116 age-matched women with at least one alive child and without any history of pregnancy loss or other gestational complications (n = 116).
Following DNA extraction, samples were tested for MTHFR C677T and A1298C polymorphisms using the reverse hybridization method.
Results : The prevalence of 677TT mutation was 8.8% (18 / 204) in the patient group and 8.6 % (10 / 116) in the control group (P = 0.434).
The prevalence of 1298CC mutation was 12.3 % (25 / 204) in the patient group and 8 % (9 / 116) in the control group (P = 0.155).
Investigation of the distributions of various genotypes of MTHFR C677T and A1298C did not indicate a significant difference between patients with RPL and healthy control subjects.
Conclusions : The results suggest that MTHFR mutations might not be associated with RPL in the examined population.
American Psychological Association (APA)
Yusufian, Ilham& Kardi, Muhammad Taqi& al-Hafizi, Azra. 2014. Methylenetetrahydrofolate reductase C677T and a1298C polymorphism in Iranian women with idiopathic recurrent pregnancy losses. Iranian Red Crescent Medical Journal،Vol. 16, no. 7, pp.1-4.
https://search.emarefa.net/detail/BIM-387524
Modern Language Association (MLA)
Yusufian, Ilham…[et al.]. Methylenetetrahydrofolate reductase C677T and a1298C polymorphism in Iranian women with idiopathic recurrent pregnancy losses. Iranian Red Crescent Medical Journal Vol. 16, no. 7 (Jul. 2014), pp.1-4.
https://search.emarefa.net/detail/BIM-387524
American Medical Association (AMA)
Yusufian, Ilham& Kardi, Muhammad Taqi& al-Hafizi, Azra. Methylenetetrahydrofolate reductase C677T and a1298C polymorphism in Iranian women with idiopathic recurrent pregnancy losses. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 7, pp.1-4.
https://search.emarefa.net/detail/BIM-387524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3-4
Record ID
BIM-387524