MS14, a marine herbal medicine, an immunosuppressive drug in experimental autoimmune encephalomyelitis
Joint Authors
Rad, Jafar Sulaymani
Kalan, Abbas Ibrahimi
Kafami, Laya
Muhammadnezhad, Daryoush
Khaki, Amir Afshin
Rawshandah, Amanh Muhammadi
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 7 (31 Jul. 2014), pp.1-6, 6 p.
Publisher
Publication Date
2014-07-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Cytokines are secreted signaling proteins which play essential roles in immune responses during experimental autoimmune encephalomyelitis (EAE), a demyelinating model that mimics many features of multiple sclerosis (MS).
Interleukin 6 (IL-6) is a multifunctional cytokine produced by different cells, mediating inflammatory reactions and immune-mediated processes.
Several studies have described immunosuppressive potentials of several herbal medicines.
MS14 as an Iranian marine herbal medicine has anti-inflammatory and immunomodulatory activities.
Objectives : The present study investigated the immunosuppressive potential of MS14 as an herbal drug as well as the IL-6 level in EAE model.
We hope it will be a new approach for neurologic diseases and autoimmune originated diseases therapy.
Patients and Methods : The present experimental study was a collaboration between Department of Anatomical Sciences of Tabriz University of Medical Sciences and Shefa Neuroscience Research Center of Tehran.
We used 30 C57BL/6 mice.
The animals were immunized with myelin oligodendrocyte glycoprotein (MOG) to induce EAE and treated with MS14-containing (30 %) diets.
Subjects were selected by simple random sampling and then they were randomly allocated to two groups.
EAE symptoms were assessed using the standard 10–point EAE scoring system from the seventh to the 35th day after immunization.
Afterwards, the spleen was removed and its cells were cultured with or without MOG 35-55 ; then, the IL-6 level was analyzed by ELISA.
In addition, histopathological studies were carried out for demyelination lesion evaluation in the spinal cord.
Results : MS14 significantly improved clinical symptoms of EAE compared with the control (P < 0.05).
It also suppressed proliferative responses of T cells and decreased IL-6 expression (16.93 ± 2.7 vs.
21.4 ± 3.33) (P < 0.05).
Conclusions : Our results strongly suggested that IL-6 as a potential molecule could have a role in neuroimmunology and neuroinflammation, which is in congruent with previous studies.
Therefore, it can be a clear target in strategic therapies and support effective properties of phytotherapy in EAE and MS treatment.
American Psychological Association (APA)
Kalan, Abbas Ibrahimi& Rad, Jafar Sulaymani& Kafami, Laya& Muhammadnezhad, Daryoush& Khaki, Amir Afshin& Rawshandah, Amanh Muhammadi. 2014. MS14, a marine herbal medicine, an immunosuppressive drug in experimental autoimmune encephalomyelitis. Iranian Red Crescent Medical Journal،Vol. 16, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-387569
Modern Language Association (MLA)
Kalan, Abbas Ibrahimi…[et al.]. MS14, a marine herbal medicine, an immunosuppressive drug in experimental autoimmune encephalomyelitis. Iranian Red Crescent Medical Journal Vol. 16, no. 7 (Jul. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-387569
American Medical Association (AMA)
Kalan, Abbas Ibrahimi& Rad, Jafar Sulaymani& Kafami, Laya& Muhammadnezhad, Daryoush& Khaki, Amir Afshin& Rawshandah, Amanh Muhammadi. MS14, a marine herbal medicine, an immunosuppressive drug in experimental autoimmune encephalomyelitis. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-387569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-387569