Correlation between hypertension, C-reactive protein and serum uric acid with psychological well-being

Abstract EN

Background : Multiple population-based human studies have established a strong association between increasing levels of serum C-reactive protein, uric acid and subsequent development of hypertension.

Objectives : We aimed to investigate the association between mental well-being with presence of hypertension, hyperuricemia and hs-CRP levels.

Patients and Methods : This was a cross sectional study of 801 individuals aged 35-85 years old in Broujerd, Iran, included by randomized cluster sampling.

General Health Questionnaire (GHQ-12) for assessing mental health / distress level, MONICA standard questions for evaluating hypertension history, serum hs-CRP and Serum Uric Acid (SUA) were evaluated Data were analyzed by appropriate statistical test such as chi-square, T-test and correlation.

Results : One hundred eighty five patients (23.1 %) had high distress / minor psychiatric disorders.

SUA had significant association with hypertension (r = 0.64, P = 0.034).

No significant relation was observed between hs-CRP and hypertension.

The correlation between GHQ and hs-CRP was not significant but a weak and negative correlation was found between GHQ and SUA SUA (P = 0.012, r = -0.089).

Conclusions : The weak and strong correlation among these parameters indicate that mental wellbeing relays on physical wellness and interact with each other ; therefore, controlling hypertension along with uric acid control may effect mental health of any kind of patients.