Immunization response of rabbits and Guinea pigs to different antigens of Bacillus anthracis vaccine strain
Joint Authors
Ahmad, Abbas M.
Muhammad, Layla I.
Umar, M. M.
Jumah, M. M.
Mulla, S. A.
Abu Salib, Sarah
Source
Sudan Journal of Science and Technology
Issue
Vol. 14, Issue 1 (30 Jun. 2013), pp.1-7, 7 p.
Publisher
Sudan University of Science and Technology Deanship of Scientific Research
Publication Date
2013-06-30
Country of Publication
Sudan
No. of Pages
7
Main Subjects
Topics
Abstract EN
A crude protective antigen (CPA), anthrax live spore vaccine (LS) and formaldehyde inactivated spores (FIS) of Bacillus anthracis, were prepared to evaluate their immune response in rabbits.
Also these antigens were inoculated into guinea pigs to study their protective efficacy.
In rabbits vaccinated with LS anthrax vaccine, antibodies were raised against the LS, FIS and CPA, antibodies induced against FIS and CPA has similar optical densities (ODs) but it is increased in LS.
However, rabbits inoculated with CPA, again produced antibodies against the three antigens this is due to anti- PA neutralizing and anti-spore activities.
Protective efficacy of LS, FIS and CPA in guinea pigs varied, it was 100%, 40%, and 20% respectively.
The nonvaccinated control animals died in 48 and 72 hours but most of guinea pigs inoculated with FIS and CPA died after 72 hours this might be due partial immunity acquired by the FIS and CPA.
American Psychological Association (APA)
Ahmad, Abbas M.& Muhammad, Layla I.& Umar, M. M.& Jumah, M. M.& Mulla, S. A.& Abu Salib, Sarah. 2013. Immunization response of rabbits and Guinea pigs to different antigens of Bacillus anthracis vaccine strain. Sudan Journal of Science and Technology،Vol. 14, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-388576
Modern Language Association (MLA)
Ahmad, Abbas M.…[et al.]. Immunization response of rabbits and Guinea pigs to different antigens of Bacillus anthracis vaccine strain. Sudan Journal of Science and Technology Vol. 14, no. 1 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-388576
American Medical Association (AMA)
Ahmad, Abbas M.& Muhammad, Layla I.& Umar, M. M.& Jumah, M. M.& Mulla, S. A.& Abu Salib, Sarah. Immunization response of rabbits and Guinea pigs to different antigens of Bacillus anthracis vaccine strain. Sudan Journal of Science and Technology. 2013. Vol. 14, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-388576
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 7
Record ID
BIM-388576