Does FVL have an effect on longevity?
Joint Authors
Egin, Yonca
Akar, Najat
Akin, Dilara Fatimah
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 15, Issue 3 (31 Jul. 2014), pp.281-285, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2014-07-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background: Different genetic and non-genetic factors have been reported to play a role in human longevity.
Longevity has been associated with genetically favourable conditions which protected humans from cardiovascular disease (CVD).
We have tried to confirm this statement in Turkish young and old aged groups.
Aim of the study: We aimed to investigate selected genetic polymorphisms (Factor V 1691 G-A, Prothrombin 20210 G-A and methylenetetrahydrofolate reductase 677 C-T) in CVD and controls to analyse their effects on longevity.
Patients and methods: The case control study included 362 persons aged 0–18 years and 209 persons aged 70 and above with diagnosis of thrombosis.
Genetic polymorphisms were detected with Light Cycler Real Time PCR.
Results: The results were compared to those of 332 and 266 healthy persons of same age groups who served as controls.
MTHFR 677 C-T and PT 20210 G-A genotype frequencies in the old and young study groups were similar for all polymorphisms, but MTHFR 677T may have synergy with FVL (Factor V Leiden) imparting a risk of thromboembolism.
Conclusion: This study concludes that common
American Psychological Association (APA)
Akin, Dilara Fatimah& Egin, Yonca& Akar, Najat. 2014. Does FVL have an effect on longevity?. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 3, pp.281-285.
https://search.emarefa.net/detail/BIM-388605
Modern Language Association (MLA)
Egin, Yonca…[et al.]. Does FVL have an effect on longevity?. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 3 (Jul. 2014), pp.281-285.
https://search.emarefa.net/detail/BIM-388605
American Medical Association (AMA)
Akin, Dilara Fatimah& Egin, Yonca& Akar, Najat. Does FVL have an effect on longevity?. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 3, pp.281-285.
https://search.emarefa.net/detail/BIM-388605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 284-285
Record ID
BIM-388605