Haptoglobin phenotypes as a risk factor for coronary artery disease in type 2 diabetes mellitus: an Egyptian study

Abstract EN

-Objective: Diabetes has long been known to be an independent risk factor for cardiovascular disease.

Recognition of diabetic individuals at greatest risk of developing coronary artery disease (CAD) would have important public health importance by allowing the distribution of limited resources to be directed on those who would most benefit from aggressive management.

Several functional differences between haptoglobin (Hp) phenotypes have been demonstrated that appear to have important biological and clinical consequences in the development of CAD in patients with type 2 DM.

The present study was conducted to demonstrate the relationship between Abbreviations: Hp, haptoglobin; CAD, coronary artery disease; DM, diabetes mellitus; CRP, serum C-reactive protein; PCR, polymerase chain reaction; ECG, electro-cardiograph; SBP, systolic blood pressure; DBP, diastolic blood pressure; FBS, fasting blood sugar; 2hsBS, 2 hours postprandial blood glucose; HbA1c, glycated hemoglobin; TC, total cholesterol; TG, triglycerides; LDL-c, low density Lipoprotein cholesterol; HDL-c, high density lipoprotein cholesterol.