Terminalia catappa, an anticlastogenic agent against MMS induced genotoxicity in the human lymphocyte culture and in bone marrow cells of albino mice

Abstract EN

-Background: Terminalia catappa has been used as a folk medicine for treating dermatitis, hepatitis as well as other diseases in India.

It possesses anticancer, antioxidant as well as anticlastogenic characteristics.

Aim: The aim of the present investigation is to highlight the anticarcinogenic and antimutagenic potential of extracts of T.

catappa.

Subjects: Anticarcinogenic potential of methanolic extract of T.

catappa has been tested against the carcinogenicity induced by methyl methanesulfonate in the in vitro and in vivo models.

Methods: The parameters for evaluation included chromosomal aberrations (CA), sister chromatid exchanges (SCEs) and replication indices (RI) both in the presence as well as in the absence of exogenous metabolic activation system (in vitro study) and total aberrant cells and the frequencies of aberrations were used (for in vivo methods).

Background: Terminalia catappa has been used as a folk medicine for treating dermatitis, Abbreviations: CA, chromosomal aberrations; SCE, sister chromatid exchanges; RI, replication index; MMS, methyl methanesulfonate; DMSO, dimethyl sulfoxide; ATE, alcoholic Terminalia catappa hepatitis as well as other diseases in India.

It possesses anticancer, antioxidant as well as anticlastogenic characteristics.

Aim: The aim of the present investigation is to highlight the anticarcinogenic and antimutagenic potential of extracts of T.

catappa.

Subjects: Anticarcinogenic potential of methanolic extract of T.

catappa has been tested against the carcinogenicity induced by methyl methanesulfonate in the in vitro and in vivo models.

Methods: The parameters for evaluation included chromosomal aberrations (CA), sister chromatid exchanges (SCEs) and replication indices (RI) both in the presence as well as in the absence of exogenous metabolic activation system (in vitro study) and total aberrant cells and the frequencies of aberrations were used (for in vivo methods).Background: Terminalia catappa has been used as a folk medicine for treating dermatitis, hepatitis as well as other diseases in India.

It possesses anticancer, antioxidant as well as anticlastogenic characteristics.

Aim: The aim of the present investigation is to highlight the anticarcinogenic and antimutagenic potential of extracts of T.

catappa.

Subjects: Anticarcinogenic potential of methanolic extract of T.

catappa has been tested against the carcinogenicity induced by methyl methanesulfonate in the in vitro and in vivo models.

Methods: The parameters for evaluation included chromosomal aberrations (CA), sister chromatid exchanges (SCEs) and replication indices (RI) both in the presence as well as in the absence of exogenous metabolic activation system (in vitro study) and total aberrant cells and the frequencies of aberrations were used (for in vivo methods).Background: Terminalia catappa has been used as a folk medicine for treating dermatitis, hepatitis as well as other diseases in India.

It possesses anticancer, antioxidant as well as anticlastogenic characteristics.

Aim: The aim of the present investigation is to highlight the anticarcinogenic and antimutagenic potential of extracts of T.

catappa.

Subjects: Anticarcinogenic potential of methanolic extract of T.

catappa has been tested against the carcinogenicity induced by methyl methanesulfonate in the in vitro and in vivo models.

Methods: The parameters for evaluation included chromosomal aberrations (CA), sister chromatid exchanges (SCEs) and replication indices (RI) both in the presence as well as in the absence of exogenous metabolic activation system (in vitro study) and total aberrant cells and the frequencies of aberrations were used (for in vivo methods).