The toxicological effects of the herbicide 2,4-D. C. P. A. on progesterone levels and mortality in Wistar female rats

Abstract EN

The effect of the ester butylglucol of 2,4-Dichlorophenoxyacetic acid (herbicide) on the rate of fertilization and on progesterone levels during gestation in rats, has been studied.

The experiments consisted of four groups; one receiving the drug in the drinking water at a concentration of 125 mg/kg/day (the agriculture dose), the second and the third group received per os doses of 50 and 100 mg/kg/day of the herbicide, while the fourth group served as controls.

The obtained results show that all treatments lead to a decrease in both indexes of females' fertility and in that of newborn mortality.

On the other hand, the index of fertilization has been highly affected by the drug application, with a clear delay in fertilization in animals treated with 100 mg/kg/day and 125 mg/kg/day.

Progesterone levels have also been suppressed in individuals receiving the herbicide at 50 and 125 mg/kg/day.