Mathematical modeling and simulation of imperfect mixing in bioreactors
Source
The Arabian Journal for Science and Engineering. Section B, Engineering
Issue
Vol. 23, Issue 2B (31 Oct. 1998), pp.177-195, 19 p.
Publisher
King Fahd University of Petroleum and Minerals
Publication Date
1998-10-31
Country of Publication
Saudi Arabia
No. of Pages
19
Main Subjects
Engineering & Technology Sciences (Multidisciplinary)
Abstract EN
n this study, a scale-down approach has been used for the simulation of imperfect mixing in growth processes by considering a configuration of two backmix flow reactors (the first one is aerated but the second one is not aerated) and one plug flow tubular j reactor (not aerated).
The steady-state concentrations of biomass and enzyme in a continuous culture were calculated as a function of dilution rate using modified Monod growth kinetics.
A mathematical model for this combination of three bioreactors was developed to account for growth, substrate utilization (oxygen and glucose), and enzyme synthesis and decay.
The model was then used to investigate biomass production and , enzyme expression in relation to the recirculation ratio and the volumetric fraction of the plug flow tubular reactor, the interchange flow rate and the volume fraction of the second backmix flow reactor of the fermentation system.
All these parameters were found to be significant factors in the biomass and enzyme production from the combined fermentation system.
This model was also compared with some of the existing models.
American Psychological Association (APA)
Ozbek, Belma. 1998. Mathematical modeling and simulation of imperfect mixing in bioreactors. The Arabian Journal for Science and Engineering. Section B, Engineering،Vol. 23, no. 2B, pp.177-195.
https://search.emarefa.net/detail/BIM-389901
Modern Language Association (MLA)
Ozbek, Belma. Mathematical modeling and simulation of imperfect mixing in bioreactors. The Arabian Journal for Science and Engineering. Section B, Engineering Vol. 23, no. 2B (Oct. 1998), pp.177-195.
https://search.emarefa.net/detail/BIM-389901
American Medical Association (AMA)
Ozbek, Belma. Mathematical modeling and simulation of imperfect mixing in bioreactors. The Arabian Journal for Science and Engineering. Section B, Engineering. 1998. Vol. 23, no. 2B, pp.177-195.
https://search.emarefa.net/detail/BIM-389901
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 194-195
Record ID
BIM-389901