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Improvements in the diagnosis of acute kidney Injury
Joint Authors
Melnikov, Vyacheslav Y.
Molitoris, Bruce A.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 19, Issue 4 (31 Aug. 2008), pp.537-544, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2008-08-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Acute kidney injury (AKI) represents a wide range of heterogeneous clinical conditions with a high mortality rate.
Despite improvements in our understanding of the disease processes, mortality has only marginally improved and remains unacceptably high.
An additional consequence of AKI is the marked acceleration of pre-existing chronic kidney disease to endstage renal disease.
A major limitation in improving outcomes of AKI has been the lack of common standards for diagnosis and severity stratification.
Serum creatinine is a late marker of kidney dysfunction and injury.
Presently, no available commercial test offers diagnosis, nor the ability to stratify patients by severity of injury, early in the course of disease when therapy may be beneficial.
The Acute Dialysis Quality Initiative (ADQI) group proposed a standard definition and classification system for the syndrome of acute renal failure.
Based on data that even small changes of serum creatinine result in increased mortality, the Acute Kidney Injury Network (AKIN) has recently proposed modified criteria.
Both staging systems emphasize changes in serum creatinine and urine output.
There is also potential that a number of serum and urine bio-markers developed in preclinical studies and currently being investigated and validated, will enable the early diagnosis of AKI.
American Psychological Association (APA)
Melnikov, Vyacheslav Y.& Molitoris, Bruce A.. 2008. Improvements in the diagnosis of acute kidney Injury. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 4, pp.537-544.
https://search.emarefa.net/detail/BIM-39000
Modern Language Association (MLA)
Melnikov, Vyacheslav Y.& Molitoris, Bruce A.. Improvements in the diagnosis of acute kidney Injury. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 4 (Dec. 2008), pp.537-544.
https://search.emarefa.net/detail/BIM-39000
American Medical Association (AMA)
Melnikov, Vyacheslav Y.& Molitoris, Bruce A.. Improvements in the diagnosis of acute kidney Injury. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 4, pp.537-544.
https://search.emarefa.net/detail/BIM-39000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 543-544
Record ID
BIM-39000