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The effects of inhaled corticosteroids on bone mineral density in male patients with bronchial asthma
Joint Authors
Atum, Ali
al-Ghuwayri, Ali
al-Khawalidah, Khalid
al-Zurayqat, Abd Allah
al-Rifai, Ali
al-Rawashidah, Abd al-Basit
al-Nadi, Khalid
al-Khazaligh, Muhammad
Source
Journal of the Royal Medical Services
Issue
Vol. 21, Issue 2 (30 Jun. 2014), pp.31-35, 5 p.
Publisher
The Royal Medical Services Jordan Armed Forces
Publication Date
2014-06-30
Country of Publication
Jordan
No. of Pages
5
Main Subjects
Topics
Abstract EN
Objective : the aim of the study is to assess the effect of Inhaled steroids on bone density in male patients with bronchial asthma.
Methods : this retrospective analysis included 102 male patients with bronchial asthma, mean age 51 years (range ; 22-80).
All has been using inhaled beclomethasone dipropionate or budesonide with average dosage of 800 ug / day (600- 1200) at least for the last year.
Patients then were subdivided into 3 groups according to duration of inhalational steroid use: group 1: < 5years (n = 17), group 2: 5-10 years (n = 57) and group 3: >10years (n = 28).
Bone mineral density was measured from lumbar spine (L1-4) and non dominant proximal femur by dual energy X-Ray absorptiometry with a Hologic QDR-IO00 densitometer (Holologic Inc., Waltham, Mass).
ANOVA test was used in statistical analysis and P < 0.05 was considered significant Results : Over all frequency of osteoporosis and osteopenia within our study group were 48 % and 43 % respectively.
In the left femur, those values were 58 % and 8 % respectively.
Frequency of osteoporosis in lumbar vertebrae and left femur in the above 3 groups classified according to duration of inhalational steroid use were: group 1: 6 % & 0 %, Group 2: 42 % & 9 % and group 3: 71 % &5 % respectively.
BMDs, T-scores and Z- scores were lower in group 2 and 3 compared to group 1(p < 0.05).
Conclusion : our study shows high frequency of osteoporosis among men treated with inhalational steroids.
Therefore, screening strategy is recommended within 5 years after initiation of treatment.
American Psychological Association (APA)
al-Khawalidah, Khalid& al-Zurayqat, Abd Allah& Atum, Ali& al-Rifai, Ali& al-Rawashidah, Abd al-Basit& al-Khazaligh, Muhammad…[et al.]. 2014. The effects of inhaled corticosteroids on bone mineral density in male patients with bronchial asthma. Journal of the Royal Medical Services،Vol. 21, no. 2, pp.31-35.
https://search.emarefa.net/detail/BIM-390317
Modern Language Association (MLA)
al-Khazaligh, Muhammad…[et al.]. The effects of inhaled corticosteroids on bone mineral density in male patients with bronchial asthma. Journal of the Royal Medical Services Vol. 21, no. 2 (Jun. 2014), pp.31-35.
https://search.emarefa.net/detail/BIM-390317
American Medical Association (AMA)
al-Khawalidah, Khalid& al-Zurayqat, Abd Allah& Atum, Ali& al-Rifai, Ali& al-Rawashidah, Abd al-Basit& al-Khazaligh, Muhammad…[et al.]. The effects of inhaled corticosteroids on bone mineral density in male patients with bronchial asthma. Journal of the Royal Medical Services. 2014. Vol. 21, no. 2, pp.31-35.
https://search.emarefa.net/detail/BIM-390317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 35
Record ID
BIM-390317