P53 over expression in gastric carcinoma : an immunohistochemical study in Nineveh Province

Abstract EN

Objective : The current study aims to evaluate the immunohistochemical over-expression of p53 in patients with gastric carcinoma, and correlate it with certain clinicopathological parameters such as age and sex of the patients, types and grade of the cancer, the depth of invasion of gastric carcinoma and the status of lymph node involvement, and compare the results of this study with those of others.

Methods : This is a case series study, a total of 50 cases of gastric carcinoma (15 were gastrectomy specimens either partial or total and 35 were endoscopical biopsies) were collected from Al-Salaam and Al-Jumhori Teaching Hospitals and some private laboratories in Nineveh Province, during a period of two years extending from February 2011 to February 2013.

The tumors were typed according to the Lauren’s classification system.

The over-expression of p53 was evaluated immunohistochemically.

Results : The overall p53 over-expression in gastric carcinoma was 62 %.

The patients age ranged from 30 to 90 years (mean 59.3 year).

In this study, 66 % of the patients were males, and 34 % were females With male to female ratio of 1.9:1.

There was no significant relationship between the age and sex of the patients and p53 over-expression in gastric carcinoma.

Histopathological typing revealed that 64 % of the cases were of intestinal type and 36 % were of diffuse type.

A statistically significant association was found between p53 over-expression and the type of gastric carcinoma.

In intestinal type, the p53 over-expression was detected in 83.9 %, whereas it was detected in 16.1 % only in diffuse type.

There was a significant direct relation between the p53 over-expression on one hand and the grade of intestinal type of gastric carcinoma and the depth of tumor invasion on the other hand.

Lymph node with metastasis was seen in 66.7 %.

Positive p53 over-expression was seen in 90 % of lymph node with metastasis.

There was a significant relation between p53 over-expression and the status of lymph node involvement.

Conclusions : P53 was over-expressed in 62 % of gastric carcinoma in Nineveh Province.

It was significantly over-expressed in intestinal type of gastric carcinoma compared to diffuse type of gastric carcinoma.

P53 over-expression was directly related to the grade of intestinal type of gastric carcinoma, the depth of tumor invasion and the status of lymph node involvement.