Effect of nitrate administration on serum protein, some enzymes and weight of rabbits

Abstract EN

The effect of daily oral administration of nitrate on serum total protein, albumin, globulin, transaminases (AST and ALT) and alkaline phosphatase (AP) in rabbits blood serum and body weight increment rate at various intervals during 30 days were studied.

The data showed clearly that rabbits body weight increment rate decreased significantly in thirty days of inoculation as a result of nitrate oral administration.

Administration of 300mg NaNC>3 /kg b.w.

caused a decrease in the body weight increment rate by 27.19%compared with the control group.

Total protein concentration in rabbits serum also affected by sodium nitrate daily administration, hence, it decreased significantly by 27.71, 32.11, 23.85 and 15.04% in response to the treatment by 25,75,150 and 300 mg NaN03 / kg b.w.

for 20 days .

It was obvious that the increment in albumin level coincided with the increment dose of sodium nitrate.

However, a significant decrease in globulin concentration was observed after 20 days of nitrate administration.

On the other hand, Administration of 75 or 150 mg NaN03 /kg b.w.

daily for 30 days caused an increase in the activity of ALT by about 33% compared with the control rabbits.

The activity of AP increased, in general, significantly in response to sodium nitrate administration at levels of 75, 150 and 300 mg/kg b.w.

for 20 days by 7.67, 42.49 and 30.88%, respectively.