Development of a cell culture attenuated vaccine against lumpy skin disease part (1) : pathogenicity and immunogenicity of high culture-passaged viruses
Joint Authors
Abd al-Rauf, Yazid
Muhammad, Muhammad Hamid al-Fatih
Ali, Ba Bakir al-Hajj
Source
Journal of Science and Technology
Issue
Vol. 4, Issue 2 (31 Dec. 2003), pp.59-81, 23 p.
Publisher
Sudan University of Science and Technology Deanship of Scientific Research
Publication Date
2003-12-31
Country of Publication
Sudan
No. of Pages
23
Main Subjects
Abstract EN
After 54 passages in bovine kidney cell (BKC) culture and clonal selection, a Sudancese isolate of "Neethling" type virus, designated "Massalamia", though found to be capable of protecting zebu cattle against virulent challenge of lumpy skin disease virus (LSDV), could produce adverse post-vaccinal clinical reaction and it grew poorly in BKC cutlure.
However, after 66th passages and clbnai selection it grew vigorously in BKC culture and caused no such adverse effects, yet it was still capable of protecting zebu cattle against challenge of the virus.
All animals vaccinated with either passage levels were hypersensitive to an inactivated LSD viral antigen and to the intradermal LSDV challenge, while only those with post-vaccinal localized reaction developed in addition a significant neutralizing antibody response.
The antibody response to the 54th passage level was higher than which followed vaccination with the 66th passage level irrespective of the dose of the virus inoculated
American Psychological Association (APA)
Abd al-Rauf, Yazid& Muhammad, Muhammad Hamid al-Fatih& Ali, Ba Bakir al-Hajj. 2003. Development of a cell culture attenuated vaccine against lumpy skin disease part (1) : pathogenicity and immunogenicity of high culture-passaged viruses. Journal of Science and Technology،Vol. 4, no. 2, pp.59-81.
https://search.emarefa.net/detail/BIM-391630
Modern Language Association (MLA)
Abd al-Rauf, Yazid…[et al.]. Development of a cell culture attenuated vaccine against lumpy skin disease part (1) : pathogenicity and immunogenicity of high culture-passaged viruses. Journal of Science and Technology Vol. 4, no. 2 (2003), pp.59-81.
https://search.emarefa.net/detail/BIM-391630
American Medical Association (AMA)
Abd al-Rauf, Yazid& Muhammad, Muhammad Hamid al-Fatih& Ali, Ba Bakir al-Hajj. Development of a cell culture attenuated vaccine against lumpy skin disease part (1) : pathogenicity and immunogenicity of high culture-passaged viruses. Journal of Science and Technology. 2003. Vol. 4, no. 2, pp.59-81.
https://search.emarefa.net/detail/BIM-391630
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 76-79
Record ID
BIM-391630