Antibacterial activity of meropenem loaded to chitosan matrix

Abstract EN

The antimicrobial activity of Meropenem released from chitosan matrix against gram positive and gram negative bacteria were studied.

The inhibition zone diameter were determined After (24,48) hrs of incubation using agar diffusion assay.

The results showed that both matrices were very active to deliver the antibiotic .there are significant increasing p < 0.05 in inhibition zone after 48 hrs compared with 24 hrs of incubation.

In 100 and 200mg of chitosan loaded with meropenem Also there is significant p < 0.05 increasing in the antibiotic delivery in 200 mg chitosan matrix.

This study suggest to use such matrices in drug delivery system for local bioavailability of compound antibiotic against gram positive and gram negative bacteria at the same time which is very important in the treatment of some bacterial infections.