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β2-glycoprotein-l antibody in type 2 diabetes mellitus
Joint Authors
Shalbayah
Butrus
Shuayb
Abd al-Aziz
Source
Egyptian Journal of Applied Endocrinology
Issue
Vol. 18, Issue 2 (31 Jul. 2000), pp.95-108, 14 p.
Publisher
The Egyptian Society of Applied Endocrinology
Publication Date
2000-07-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Topics
Abstract EN
Antiphospholipid antibodies (APL) are antibodies that recognize epitopes formed by anionic phospholipids and protein cofactors.
Beta 2-glycoprotein-I (j32-GP-I) is the cofactor for binding of anticardiolipin antibodies to their ligands.
Our work aims at studying the possible relation between (32 GP-1 antibodies and coronary artery disease in diabetics.
We conducted a case-control study comprising 80 subjects; 20 healthy control subjects (Group 1), 20 type 2 diabetics [T2DM] with coronary artery disease [CAD] (Group 2), \ 20 obese T2DM without CAD (Group 3) and 20 non-obese T2DM without | CAD (Group 4).
Antibody to (32glycoprotein 1 ((32-GP-l IgG) was measured | in sera of the 80 subjects by ELISA technique.
Diabetics with IHDhad a ‘ significantly higher titer of anti-(32 GP-1 (12.85± 1.04 SGU) when compared i to both groups of diabetics without IHD (12.04± 0.63 SGU;p < 0.001)and j when compared to each group alone (12.04 ± 0.34 SGU for obese diabetics, p I < 0.001 and 12.12 ± 0.83 SGU for non-obese diabetics, p > 0.01).
However, | control group had a titer which was not significantly different from diabetics j with IHD ( p > 0.05), but was higher than diabetics without IHD (p < 0.01 I for comparison with the obese group and < 0.05 for comparison with the j non-obese group).
The diabetics with CAD differed from diabetics without CAD only in having a higher BMI, W/Hratio and a lower HDL level; they not differ in age, duration of diabetes, blood pressure, glycemic indices, ttbAlc, total cholesterol, LDL cholesterol or triglycerides.
We conclude that ti-(32-GP-l IgG may play a role in predisposing to or precipitating c°ronary artery events in diabetics.
Whether it is a primary abnormality or 3n epiphenomenon to atherosclerosis will need further study.
American Psychological Association (APA)
Shalbayah& Butrus& Shuayb& Abd al-Aziz. 2000. β2-glycoprotein-l antibody in type 2 diabetes mellitus. Egyptian Journal of Applied Endocrinology،Vol. 18, no. 2, pp.95-108.
https://search.emarefa.net/detail/BIM-393049
Modern Language Association (MLA)
Shalbayah…[et al.]. β2-glycoprotein-l antibody in type 2 diabetes mellitus. Egyptian Journal of Applied Endocrinology Vol. 18, no. 2 (Jul. 2000), pp.95-108.
https://search.emarefa.net/detail/BIM-393049
American Medical Association (AMA)
Shalbayah& Butrus& Shuayb& Abd al-Aziz. β2-glycoprotein-l antibody in type 2 diabetes mellitus. Egyptian Journal of Applied Endocrinology. 2000. Vol. 18, no. 2, pp.95-108.
https://search.emarefa.net/detail/BIM-393049
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 81
Record ID
BIM-393049