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Metabolic changes and thyroid hormones profile in iron deficient rats
Author
Abd al-Aziz, Muhammad al-Sayyid
Source
Egyptian Journal of Applied Endocrinology
Issue
Vol. 19, Issue 1-2 (31 Jul. 2001), pp.57-71, 15 p.
Publisher
The Egyptian Society of Applied Endocrinology
Publication Date
2001-07-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Topics
Abstract EN
Iron deficiency is a major nutritional problem.lt may exert numerous haematologic and metabolic consequences that nearly simulate those that occure in diabetes mellitus.
In addition, it may produce endocrine changes e.g.; abnormal thyroid hormones metabolism.
Twenty eight male albino rats were used distributed equally into two groups: iron deficient group (I D) and iron sufficient control group .
The duration of the experiment was 6 weeks.
This study revealed that nutritional iron deficiency produced significant reduction of packed cell volume (PCV) and hemoglobin content (Hb) associated with significant hyperglycemia and increased glucose uptake by peripheral tissues (diaphragm).
Also, iron deficiency caused marked reduction of plasma thyroid hormones level(T3&T4) associated with altered plasma lipoproteins profile such as marked increase in plasma levels of total cholesterol, LDL-C and atherogenic index as well as reduction of HDL-C compared to iron sufficient controls.
It can be concluded that, iron deficiency is a direct risk factor for the development of metabolic and thyroid function perturbances.
This risk is primarily due to iron deficiency per se and/or anemia.
So, prevention and treatment of iron deficiency is recommended to minimize these pertubances.
American Psychological Association (APA)
Abd al-Aziz, Muhammad al-Sayyid. 2001. Metabolic changes and thyroid hormones profile in iron deficient rats. Egyptian Journal of Applied Endocrinology،Vol. 19, no. 1-2, pp.57-71.
https://search.emarefa.net/detail/BIM-393216
Modern Language Association (MLA)
Abd al-Aziz, Muhammad al-Sayyid. Metabolic changes and thyroid hormones profile in iron deficient rats. Egyptian Journal of Applied Endocrinology Vol. 19, no. 1-2 (Jan. / Jul. 2001), pp.57-71.
https://search.emarefa.net/detail/BIM-393216
American Medical Association (AMA)
Abd al-Aziz, Muhammad al-Sayyid. Metabolic changes and thyroid hormones profile in iron deficient rats. Egyptian Journal of Applied Endocrinology. 2001. Vol. 19, no. 1-2, pp.57-71.
https://search.emarefa.net/detail/BIM-393216
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 68-71
Record ID
BIM-393216