Relation between thyroid function and anti-thyroid peroxidase antibodies in type 1 and type II diabetics

Abstract EN

This objective of this study was to clarify the possible relation between dysfunction & diabetic control.

The study included 20 healthy controls and 73 adult diabetic patients; 38 were IDDM (19 males and 19 females) and 35 were NIDDM (14 males and 21 females).

All the poorly controlledjdiabetic patients with or without complications showed thyroid-hormone abnormalities.

HbA, was used as an index of hyperglycemia.

TSH, T3,T4, insulin and anti-thyroid peroxidase (anti-TPO) antibody levels were estimated for the patients and controls, by using EIA and R1A methods, serum T3 was decreased in all uncontrolled diabetic subgroups in both types (IDDM and NIDDM).

There was a negative correlation between T3 and HbAl.

T4 levels were significantly higher in NIDDM patients than those in the IDDM and control group.

TSH levels were significantly higher in the uncontrolled diabetic patients than in the controls.

Serum anti-TPO ab levels were higher in uncontrolled diabetics subgroups.

In the present study 30.6% of the IDDM and 20% of the NIDDM patients had positive anti-TPO ab.

All the previous abnormalities in the levels of TSH, T3,T4 and anti-TPO ab were not detected in well controlled diabetic patients.

Meanwhile non significant difference was found between the levels of the previous parameters in IDDM versus NIDDM group.

fo conclusion ,thyroid function and thyroid automimmunity should be screened annually ln diabetic patients to detect asymptomatic thyroid dysfunction, and to avoid some of Me pitfalls that can occur when these two diseases exist in the same patient.