Role of plasma homocysteine concentration in type-l-diabetes with and without nephropathy

Abstract EN

homocysteine (tHcy) as a marker of endothelial cell dysfunction its to investigate ils possible role in type 1 diabetes (IDDM) with nephropathy.

Design : A randomized group comparative and cross sectional study.

Patients: A total of 60 type 1 diabetic patients.

40 of them were complicated with nephropathy.

20 patients without complication (s) and 20 healthy control subjects matched for sex and age.

Setting: Suez Canal University Hospital Main outcome measures : Fasting plasma concentration of tHcy was estimated by immunoenzymatic assay hemoglobin was measured by affinity chromatographic method.

Albumin excretion rate was determined by immunturhidometric method.

Fasting blood glucose was determined by glucose oxidase method and serum creatinine was measured by alkaline picrate method.

Results : Type 1 (IDDM) patients with nephropathy showed a significant increase of the fasting plasma tHcy levels compared to controls and those patients without complications.

٨ significant positive correlation was observed between lasting tHcy and albumin excretion rate (AER) in patients with diabetic nephropathy.

Also iHcy had positive significant correlation with serum creatinine and HbAlc.

Meanwhile there was no Signilicani correlation between tHcy and the following parameters, age, duration ofdiabetes and hody mass index (BMl).

Conclusion: tHcy was increased in type 1 diabetic patients With nephropathy, tHcy was significantly correlated to AER serum creatinine and HbAlc m type 1 diabolic patients With nephropathy tHcy contribute to enhanced rate of vascular complications observed in type 1 diabetic patients, tHcy can be an important risk factor that worsen prognosis.