Transedermal nitric oxide donor for prevention of pre-term labor high risk group of patients

Abstract EN

Introduction : Pre term labor remains the single most important contributor to infant morbidity and mortality.

Aim of the study: The present study has been planning to investigate the possibility of use nitric oxide donor as prophylactic tocolytic in high risks women for pre term labor as an out patient management in under developed health care setting.

Subjects and methods : Forty women with risk factors for pre term delivery were recruited from out patient clinic at AI Kuwait University Hospital in Sana'a, Yemen.

Women who agreed to receive the medical treatment of nitric oxide donor were categorized as group I and those Who wislt no medical treatment as group II.

All women were subjected to abdominal ultrasound for assessment of the fetus and transperineal ultrasound for assessment of cervical length, dilatation and fttnnelling of the internal OS, a midstream urine and vagina! swab for culture were taken.

Heath education program were given to all women.

Results : Transperineal ultrasound ex^nation for cervical length, dilatation and funnelling were similar in both group.

Bacteri©tog؛cal investigation for urine and vaginal swab during the study period at 28 and 32 weeks of gestation revealed no significant differences between the two groups.

10 women out of 16 (62.5 %) received transdermal titrologlycerine patches were succeed to reach to complete 37 weeks gestation while only 4 women out 18) 025 %) in the group 11 succeed to reach 37 weeks of gestation, A significant difference in the primaty end point (reaching complete 37 weeks gestation) was found tetween the two groups.

Conclusions: Transdermal nitroglycerine patches is safe to be given to pregnant women with high risk of pre term tabor in outpatient clinic with ntinimum heed for close monitoring.

Nitric oxide is an effective prophylaxis tocolytic agent that allows a prolongation of pregnancy and improvement in the neonatal outcome.