Influence of postoperative monophasic combined contraceptive pills for ovarian endometriosis on leptin serum levels

Abstract EN

Objective : to evaluate the effectiveness as well as effect on serum leptin of combined monophasic contraceptive pills in patients with endometriosis after laparoscopic excision.

Study design.

Prospective randomized controlled study.

50 patients were included after having laparoscopic excision of endometriosis followed by postoperative monophasic combined contraceptive pills for 6 months in 25 cases or no treatment in the other 25 patients.

Serum leptin level studied in both groups after surgery and 6 months later.

Results : there were no significant difference between all groups in serum leptin levels one week after surgery and after 6 months.

By life table analysis recurrence rate was significantly lower in oral contraceptive pills groups at 12 month postoperative, where no significant difference at 24 month.

Conclusion : Postoperative low dose monophasic combined contraceptive pills does not significantly affect long term recurrence of endometriosis but it does delay early recurrence.