Study of the single and combined genotoxic effects of the insecticide furadan and cadmium nitrate in aspergillus terreus

Abstract EN

In attempt to investigate the genotoxicity of the insecticide Furadan and the heavy metal cadmium in the form of cadmium nitrate in Aspergillus terreus, two main treatments were involved: 1.

Single treatment, which consists of: a - Treating the conidia of the fungus with three different concentrations of Furadan (0.3g/10ml, 0.35g/10ml and 0.4g/10ml conidial suspension.) for 0, 15, 30, 45, 60 minutes of exposure, b - Treating the conidia with three different concentration of cadmium nitrate (0.0038g/10ml, 0.038g/10ml and 0.38g/10ml) for 0, 15, 30, 45, 60 minutes of exposure.

2.

Combined treatment, which also consists of: a.

Treating the conidia with the optimal dose of Furadan followed by the optimal dose of cadmium nitrate, and vise versa in b In c - the conidia were treated by a mixture of the optimal doses of the two substances.

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As a results, it was observed in both of the two single treatments that, the increase of Furadan or cadmium nitrate concentration and exposure time, was always met by a decrease in survivals and an increase up to a certain peak in mutation frequency.Whereas, an antagonistic effect on both lethals and mutation induction was obtained in the first two combined treatments, and a synergistic effect on induced mutation occurred in the final combined treatment.