Thioacetamide-induced acute hepatic encephalopathy in rat : behavioral, biochemical and histological changes
Joint Authors
Tanideh, N
Mehrabani, D
Imanieh, M. H.
Farjam, M.
Abbassnia, F.
Pakbaz, S.
Dehdab, P.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 14, Issue 3 (31 Mar. 2012), pp.164-170, 7 p.
Publisher
Publication Date
2012-03-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Abstract EN
Background: As a serious neuropsychiatric disease, hepatic encephalopathy (HE) is a clinical condition with several types regarding chronicity and clinical diversity that can develop as a complication of both acute and chronic liver failure.
This study evaluates changes in thioacetamide (TAA)-induced acute hepatic encephalopathy (AHE) in rat as an animal model.
Methods: Both genders of C57BL6, BALB/C mice and Sprague Dawley rats; (10 animals in each group) were compared for induction of AHE to clarify which animal and gender were appropriate.
The animals (10 male rats in each group) were categorized in 4 groups according to the dose of the TAA administered (200, 300 and 400 mg/kg of TAA at 24 h intervals for 4 days).
A control group was treated with solvent of TAA which was water (5 ml/kg/day).
The behavioral, biochemical markers of hepatic failure and histological aspects of thioacetamide (TAA) induced AHE and the correlation between the clinical severity and liver failure biomarkers were evaluated.
Results: Rat was shown to be an animal model of choice for AHE while the optimum dosage of TAA to induce AHE was 300 mg/kg/day at 24 h intervals for 4 days.
The behavioral score was partially correlated with the rising of some biomarkers and pathological findings.
Conclusion: Rat can be introduced as the animal of choice
American Psychological Association (APA)
Farjam, M.& Dehdab, P.& Abbassnia, F.& Mehrabani, D& Tanideh, N& Pakbaz, S.…[et al.]. 2012. Thioacetamide-induced acute hepatic encephalopathy in rat : behavioral, biochemical and histological changes. Iranian Red Crescent Medical Journal،Vol. 14, no. 3, pp.164-170.
https://search.emarefa.net/detail/BIM-396413
Modern Language Association (MLA)
Farjam, M.…[et al.]. Thioacetamide-induced acute hepatic encephalopathy in rat : behavioral, biochemical and histological changes. Iranian Red Crescent Medical Journal Vol. 14, no. 3 (Mar. 2012), pp.164-170.
https://search.emarefa.net/detail/BIM-396413
American Medical Association (AMA)
Farjam, M.& Dehdab, P.& Abbassnia, F.& Mehrabani, D& Tanideh, N& Pakbaz, S.…[et al.]. Thioacetamide-induced acute hepatic encephalopathy in rat : behavioral, biochemical and histological changes. Iranian Red Crescent Medical Journal. 2012. Vol. 14, no. 3, pp.164-170.
https://search.emarefa.net/detail/BIM-396413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 169-170
Record ID
BIM-396413