Effects of simvastatin treatment on serum adiponectin concentrations in patients with dislipidemia
Joint Authors
Ghayour Mobarhan, Majid
Muizz, Atifah
Parizadeh, Sayyid Muhammad Rida
Tavallaie, Shima
Mazidi, Muhsin
Afzali, Fariba
Adab, Afrouz
Ferns, Gordon
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 8 (31 Aug. 2014), pp.1-5, 5 p.
Publisher
Publication Date
2014-08-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Adiponectin is an adipose tissue-derived protein with anti-inflammatory properties.
Statins are a class of cholesterol-lowering drugs, widely used for treatment of cardiovascular diseases.
Objectives : In the current study, we aimed to assess the effects of simvastatin on serum levels of adiponectin in patients with dyslipidemia, recruited from Ghaem Hospital, Mashhad, Iran.
Materials and methods : A total of 102 patients with dyslipidemia were treated with simvastatin or placebo during a double-blind, cross-over, placebo-controlled trial.
The adiponectin levels were measured before and after each treatment period.
Seventy seven participants completed the study.
Results : There was a significant reduction in serum total cholesterol (approxmately 21 %), low density lipoprotein-cholesterol (LDL-C) (approxmately 28 %), and triglycerides (approxmately 11 %), after four weeks of treatment with simvastatin (P < 0.001).
Conclusions : No significant change in serum adiponectin concentrations was observed after treatment with simvastatin.
This may be because of the relatively short duration of treatment and longer treatment duration may be necessary to investigation in future studies.
American Psychological Association (APA)
Muizz, Atifah& Parizadeh, Sayyid Muhammad Rida& Tavallaie, Shima& Mazidi, Muhsin& Afzali, Fariba& Ghayour Mobarhan, Majid…[et al.]. 2014. Effects of simvastatin treatment on serum adiponectin concentrations in patients with dislipidemia. Iranian Red Crescent Medical Journal،Vol. 16, no. 8, pp.1-5.
https://search.emarefa.net/detail/BIM-397921
Modern Language Association (MLA)
Ghayour Mobarhan, Majid…[et al.]. Effects of simvastatin treatment on serum adiponectin concentrations in patients with dislipidemia. Iranian Red Crescent Medical Journal Vol. 16, no. 8 (Aug. 2014), pp.1-5.
https://search.emarefa.net/detail/BIM-397921
American Medical Association (AMA)
Muizz, Atifah& Parizadeh, Sayyid Muhammad Rida& Tavallaie, Shima& Mazidi, Muhsin& Afzali, Fariba& Ghayour Mobarhan, Majid…[et al.]. Effects of simvastatin treatment on serum adiponectin concentrations in patients with dislipidemia. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 8, pp.1-5.
https://search.emarefa.net/detail/BIM-397921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-397921