Liposome-encapsulated hemoglobin as a red blood cell substitute by reverse micelle processing, II : characterization and efficacy
Joint Authors
al-Khamis, Taha M.
Beissinger, Richard L.
Source
Mu'tah Journal for Research and Studies : Natural and Applied Sciences Series
Issue
Vol. 8, Issue 6 (31 Dec. 1993), pp.207-232, 26 p.
Publisher
Mutah University Deanship of Academic Research
Publication Date
1993-12-31
Country of Publication
Jordan
No. of Pages
26
Main Subjects
Abstract EN
This paper characterizes liposome encapsulated hemoglobin (LEH) produced by reverse micelle processing and investigated their efficacy (1).
Characterization included viscosity of LEH suspended in a colloidal albumin or dextran solutions, particle size, oxygen carrying capacity as a result of encapsulated hemoglobin (Hb) concentra-tion and its relation to the precursor Hb concentration, circulation half life and stability of encapsulated Hb as a function of storage.
Efficacy tests included material acute toxicity and animal survival as a result of blood exchange.
Results show that the LEH produced by the above method suspended in either albumin or dextran solutions, exhibit non Newtonian behavior with LEH-dextran showing higher values and asymptotic viscosity of both types of less than 10 cp and LEH-albumin samples showing values of less than 6 cp.
Particle size (diameter) was less than 3 jam, normalized oxygen caitying capacity (NOCC) value of 25-30 ml O2/ 100 ml sample and the product was stable with respect to Hb functionality to 36 days.
No acute toxicity was observed and blood exchange experiments suggested an improvement by utihzing LEH over just plasma expander.
American Psychological Association (APA)
al-Khamis, Taha M.& Beissinger, Richard L.. 1993. Liposome-encapsulated hemoglobin as a red blood cell substitute by reverse micelle processing, II : characterization and efficacy. Mu'tah Journal for Research and Studies : Natural and Applied Sciences Series،Vol. 8, no. 6, pp.207-232.
https://search.emarefa.net/detail/BIM-397967
Modern Language Association (MLA)
al-Khamis, Taha M.& Beissinger, Richard L.. Liposome-encapsulated hemoglobin as a red blood cell substitute by reverse micelle processing, II : characterization and efficacy. Mu'tah Journal for Research and Studies : Natural and Applied Sciences Series Vol. 8, no. 6 (Dec. 1993), pp.207-232.
https://search.emarefa.net/detail/BIM-397967
American Medical Association (AMA)
al-Khamis, Taha M.& Beissinger, Richard L.. Liposome-encapsulated hemoglobin as a red blood cell substitute by reverse micelle processing, II : characterization and efficacy. Mu'tah Journal for Research and Studies : Natural and Applied Sciences Series. 1993. Vol. 8, no. 6, pp.207-232.
https://search.emarefa.net/detail/BIM-397967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 231-232
Record ID
BIM-397967