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Comparison of ondansetron and meperidine for treatment of postoperative shivering : a randomized controlled clinical trial
Joint Authors
Mahoori, Ali Rida
Noroozinia, Haydar
Hasani, Ibrahim
Sultanahmadi, Maryam
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 8 (31 Aug. 2014), pp.1-4, 4 p.
Publisher
Publication Date
2014-08-31
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : The involved neurotransmitter pathways in the postoperative shivering (POS) are poorly understood.
Recently, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists have been reported to prevent POS.
We investigated the effect of ondansetron, a 5-HT3 antagonist that is used to treat postoperative nausea and vomiting, on shivering.
Objectives : This study aimed to compare the efficacy of ondansetron and meperidine in the treatment of shivering after general anesthesia.
Patients and methods : In this double-blinded randomized clinical trial, 83 patients (age range, 18-60 years) who had shivering after general anesthesia were randomly allocated to any of these three groups : Group A, (number = 27) received 4 mg of intravenous ondansetron, Group B, (number = 27) received 8 mg of intravenous ondansetron, and Group C, (number = 29) received 0.4 mg / kg of intravenous meperidine at recovery room.
The surface temperatures and the incidence as well as intensity of shivering were recorded.
Results : Shivering was controlled in 16 patients (59 %) in Group A, 22 (81 %) in Group B, and 25 (86 %) in Group C (P = 0.01).
Within each group, there were no significant differences among the surface temperature in recovery room.
Patients in groups A and B had significantly lower incidence of nausea and vomiting than group C (P = 0.01).
Conclusions : Ondansetron and meperidine have similar effects on shivering.
We concluded that 8 mg of intravenous ondansetron can control shivering and this is the dose of choice, especially in patients with POS with nausea and vomiting.
American Psychological Association (APA)
Mahoori, Ali Rida& Noroozinia, Haydar& Hasani, Ibrahim& Sultanahmadi, Maryam. 2014. Comparison of ondansetron and meperidine for treatment of postoperative shivering : a randomized controlled clinical trial. Iranian Red Crescent Medical Journal،Vol. 16, no. 8, pp.1-4.
https://search.emarefa.net/detail/BIM-398003
Modern Language Association (MLA)
Mahoori, Ali Rida…[et al.]. Comparison of ondansetron and meperidine for treatment of postoperative shivering : a randomized controlled clinical trial. Iranian Red Crescent Medical Journal Vol. 16, no. 8 (Aug. 2014), pp.1-4.
https://search.emarefa.net/detail/BIM-398003
American Medical Association (AMA)
Mahoori, Ali Rida& Noroozinia, Haydar& Hasani, Ibrahim& Sultanahmadi, Maryam. Comparison of ondansetron and meperidine for treatment of postoperative shivering : a randomized controlled clinical trial. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 8, pp.1-4.
https://search.emarefa.net/detail/BIM-398003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3-4
Record ID
BIM-398003