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Importance of neutrophil gelatinase-associated lipocalin in differential diagnosis of acute and chronic renal failure
Joint Authors
Ozkan, Seda
Durukan, Polat
Kavalci, Cemil
Duman, Ali
Sayhan, Mustafa Burak
Salt, Umar
Ipekci, Afsin
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 8 (31 Aug. 2014), pp.1-6, 6 p.
Publisher
Publication Date
2014-08-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Neutrophil Gelatinase-associated Lipocalin (NGAL) protein is easily detected in the blood and urine soon after acute renal injury.
NGAL gains features of an early, sensitive and noninvasive biomarker for acute renal injury.
Recent evidences suggest that its expression is also increased in CRF reflecting the severity of disease.
Objectives : In the present study, we aimed to investigate whether blood NGAL level plays a role in the differential diagnosis of acute and chronic renal failure.
Patients and methods : This was a prospective case-control study.
Fifty patients presented to emergency department with acute renal failure (ARF), 30 with chronic renal failure (CRF) and 20 healthy individuals as control group were included in this study.
Blood pH, HCO3-, BUN, creatinine and potassium values were evaluated in all patients.
Blood NGAL values were evaluated in all groups.
BUN, serum creatinine and NGAL values were statistically compared between patients and controls.
Results : Median NGAL levels in patients was 304.50 (29), and 60 (0) in control, which was statistically significant between the two groups (Z =-6.477, P < 0.001).
The median NGAL values were 261.50 ± 291 in ARF group and 428.50 ± 294 in CRF group.
There was a significant difference in NGAL level between ARF and CRF groups (Z =-2.52, P=0.012).
Median BUN values were 153.46 ± 82.47 in ARF group and 169.40 ± 93.94 in CRF group.
There was no significant difference in BUN value between ARF and CRF groups (P > 0.05).
Median creatinine values were 2.84 ± 2.95 in ARF group and 4.78 ± 4.32 in CRF group.
In serum creatinine values, a significant difference was found between ARF and CRF groups (P < 0.05).
Conclusions : Serum NGAL levels of ARF and CRF patients were significantly higher than healthy individuals.
In addition, NGAL values of patients with CRF were significantly higher than those of ARF.
Serum NGAL values can be used to detect renal injury and differentiate ARF and CRF.
American Psychological Association (APA)
Ozkan, Seda& Durukan, Polat& Kavalci, Cemil& Duman, Ali& Sayhan, Mustafa Burak& Salt, Umar…[et al.]. 2014. Importance of neutrophil gelatinase-associated lipocalin in differential diagnosis of acute and chronic renal failure. Iranian Red Crescent Medical Journal،Vol. 16, no. 8, pp.1-6.
https://search.emarefa.net/detail/BIM-398094
Modern Language Association (MLA)
Ozkan, Seda…[et al.]. Importance of neutrophil gelatinase-associated lipocalin in differential diagnosis of acute and chronic renal failure. Iranian Red Crescent Medical Journal Vol. 16, no. 8 (Aug. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-398094
American Medical Association (AMA)
Ozkan, Seda& Durukan, Polat& Kavalci, Cemil& Duman, Ali& Sayhan, Mustafa Burak& Salt, Umar…[et al.]. Importance of neutrophil gelatinase-associated lipocalin in differential diagnosis of acute and chronic renal failure. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 8, pp.1-6.
https://search.emarefa.net/detail/BIM-398094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6
Record ID
BIM-398094