Possible involvement of endogenous opioid peptides in the mechanism of dantrolene actions

Abstract EN

The effects of dantrolene on the release of opioid substances were studied in three different biological systems.

It was observed that dan-trolene possesses an antinociceptive activity, and an inhibitory action on the contractions of the rabbit’s jejunum, and frog’s rectus abdominis muscles.

All of these actions were antagonised by naloxone in a noncompetitive manner.

These observations may indicate that endogenous opioids are in-volved in the mechanism of dantrolene actions.-