Spectrophotometric micro determination of gold by formation of ion pair association complex with the drug ranitidine

Abstract EN

The drug ranitidine (N-[2-[[[5-[(dimethylamino) methyl] furan-2-yl] methyl] thio] ethyl] -N-methyl-2-nitroethene-1, 1-diamine hydrochlorid) forms (Xmax = 260nm) ion-pair association complex with [AuBr4]-1 at pH range 2-3 extractable with 1, 2-dichloroethane under the appropriate experimental conditions.

A calibration plot was set up from which some analytical parameters are derived.

These parameters include : linear dynamic range LDR (1-80 ^ g.

ml-1), RSD (1.

9 %), sandell sensitivity (0.0360), detection limit (0.

11ppm), Corr.

Coef (r) (0.

9988), recovery (98.

32 %), Erei (-1.

68 %) aqueous - to- organic phase ratio (5 : 4) and the mole-ratio method approved the [AuBr4]-1 : RAN as being 1 : 1 .