Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis
Joint Authors
Hachicha, Jamil
Alawi, Sabra
Maktuf, Shukri
Bounemra, Azzah
Sharaf al-Din, Khalid
Skhiri, Habib
Yaich, Sumayyah
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 25, Issue 5 (31 Oct. 2014), pp.1026-1029, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2014-10-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Post-kidney transplant erythrocytosis (PTE) is one of the hematological complications in the renal transplant patients.
While its pathogenesis still remains to be elucidated completely, a number of therapies are available for the management of PTE.
The aim of this prospective study was to investigate whether angiogenesis may be involved in the pathogenesis of post-transplant erythrocytosis by comparing its level with those of different classes of erythrocytosis [polycythemia vera (PV), idiopathic erythrocytosis and secondary erythrocytosis].
The angiogenic activity was evaluated by the assessment of the serum vascular endothelial growth factor (VEGF) levels, as one of circulating angiogenic factor, using a standardized enzyme-linked immunosorbent assay commercial kit in 13 PTE (2 F / 11 M), in 75 untreated erythrocytosis non-transplant patients and in 21 healthy subjects controls.
The results indicated that VEGF was overproduced in advanced and untreated PV patients and to a lesser degree in idiopathic erythrocytosis thus confirming an increased angiogenic activity.
However, there is no evidence of increased angiogenesis in PTE and in secondary erythrocytosis.
The absence of angiogenesis in PTE and its presence in PV is another argument that the pathogenesis of these two entities is different.
American Psychological Association (APA)
Maktuf, Shukri& Yaich, Sumayyah& Alawi, Sabra& Bounemra, Azzah& Sharaf al-Din, Khalid& Skhiri, Habib…[et al.]. 2014. Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 5, pp.1026-1029.
https://search.emarefa.net/detail/BIM-400310
Modern Language Association (MLA)
Maktuf, Shukri…[et al.]. Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 5 (2014), pp.1026-1029.
https://search.emarefa.net/detail/BIM-400310
American Medical Association (AMA)
Maktuf, Shukri& Yaich, Sumayyah& Alawi, Sabra& Bounemra, Azzah& Sharaf al-Din, Khalid& Skhiri, Habib…[et al.]. Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 5, pp.1026-1029.
https://search.emarefa.net/detail/BIM-400310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1028-1029
Record ID
BIM-400310