Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis

Joint Authors

Hachicha, Jamil
Alawi, Sabra
Maktuf, Shukri
Bounemra, Azzah
Sharaf al-Din, Khalid
Skhiri, Habib
Yaich, Sumayyah

Source

Saudi Journal of Kidney Diseases and Transplantation

Issue

Vol. 25, Issue 5 (31 Oct. 2014), pp.1026-1029, 4 p.

Publisher

Saudi Center for Organ Transplantation

Publication Date

2014-10-31

Country of Publication

Saudi Arabia

No. of Pages

4

Main Subjects

Medicine

Topics

Abstract EN

Post-kidney transplant erythrocytosis (PTE) is one of the hematological complications in the renal transplant patients.

While its pathogenesis still remains to be elucidated completely, a number of therapies are available for the management of PTE.

The aim of this prospective study was to investigate whether angiogenesis may be involved in the pathogenesis of post-transplant erythrocytosis by comparing its level with those of different classes of erythrocytosis [polycythemia vera (PV), idiopathic erythrocytosis and secondary erythrocytosis].

The angiogenic activity was evaluated by the assessment of the serum vascular endothelial growth factor (VEGF) levels, as one of circulating angiogenic factor, using a standardized enzyme-linked immunosorbent assay commercial kit in 13 PTE (2 F / 11 M), in 75 untreated erythrocytosis non-transplant patients and in 21 healthy subjects controls.

The results indicated that VEGF was overproduced in advanced and untreated PV patients and to a lesser degree in idiopathic erythrocytosis thus confirming an increased angiogenic activity.

However, there is no evidence of increased angiogenesis in PTE and in secondary erythrocytosis.

The absence of angiogenesis in PTE and its presence in PV is another argument that the pathogenesis of these two entities is different.

American Psychological Association (APA)

Maktuf, Shukri& Yaich, Sumayyah& Alawi, Sabra& Bounemra, Azzah& Sharaf al-Din, Khalid& Skhiri, Habib…[et al.]. 2014. Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 5, pp.1026-1029.
https://search.emarefa.net/detail/BIM-400310

Modern Language Association (MLA)

Maktuf, Shukri…[et al.]. Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 5 (2014), pp.1026-1029.
https://search.emarefa.net/detail/BIM-400310

American Medical Association (AMA)

Maktuf, Shukri& Yaich, Sumayyah& Alawi, Sabra& Bounemra, Azzah& Sharaf al-Din, Khalid& Skhiri, Habib…[et al.]. Angiogenic activity in the sera of patients with post-kidney transplant erythrocytosis. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 5, pp.1026-1029.
https://search.emarefa.net/detail/BIM-400310

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 1028-1029

Record ID

BIM-400310