Protective effect of acid protease inplasmodium berghei

Abstract EN

Acid protease from plasmodium berghei was purified through sephadex G-200.

Five fold purification of the enzyme was achieved.The purified enzyme contained mixture of proteins ranging between Molecular weights 27K to 66K .

Acid protease induced antibody response in mice and the animals were Partially protected upon challenge .

Antiprotease antibodies inhibited about 50% invasion of erythrocytes by merozoites in vitro.-