![](/images/graphics-bg.png)
Immunohistochemical expression of MMP1 and TIMP1 as markers of migration in Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck region : a comparative study
Joint Authors
Yunus, Wasan H.
Qasim, Zaydun M.
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 26, Issue 3 (30 Sep. 2014), pp.72-78, 7 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2014-09-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Malignant lymphoma is a term that describes primary tumors of the lymphoreticular system, almost all of which arise from lymphocytes.
MMP-1 is the most ubiquitously expressed interstitial collagenase, a subfamily of MMPs that cleaves stromal collagens.
It is also called collagenase-1.TIMPs which inhibits MMP activity and thereby restrict extracellular matrix breakdown, TIMP-1 is a stromal factor that has a wide spectrum of functions in different tissues.
Material and Methods : This study was performed on (68) formalin-fixed, paraffin-embedded blocks, histopathologically diagnosed as lymphoma (head and neck lesions).
Immunohistochemical staining of MMP1and TIMP1 was performed on each case of the study sample.
Results : The expression of MMP1was cytoplasmic, the study cases showed a 98.5 % positive reaction to MMP1, score 3 was the most common and found in 60.3 % of all cases.
The expression of TIMP1was cytoplasmic, 92.6 % of cases expressed positive reactions to TIMP1, score 1 was the most common and found in 57.4 % of all cases.
Conclusion : This study showed for the first time the effect of MMP-1 in HL, which is considered to be as an invasive and migratory cell marker.
A significant difference was found among the subtypes of NHL in relation to TIMP1, TIMP1inhibits the effect of MMP1 and as MMP1 is elevated the TIMP1 will be elevated too.
American Psychological Association (APA)
Qasim, Zaydun M.& Yunus, Wasan H.. 2014. Immunohistochemical expression of MMP1 and TIMP1 as markers of migration in Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck region : a comparative study. Journal of Baghdad College of Dentistry،Vol. 26, no. 3, pp.72-78.
https://search.emarefa.net/detail/BIM-405024
Modern Language Association (MLA)
Qasim, Zaydun M.& Yunus, Wasan H.. Immunohistochemical expression of MMP1 and TIMP1 as markers of migration in Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck region : a comparative study. Journal of Baghdad College of Dentistry Vol. 26, no. 3 (Sep. 2014), pp.72-78.
https://search.emarefa.net/detail/BIM-405024
American Medical Association (AMA)
Qasim, Zaydun M.& Yunus, Wasan H.. Immunohistochemical expression of MMP1 and TIMP1 as markers of migration in Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck region : a comparative study. Journal of Baghdad College of Dentistry. 2014. Vol. 26, no. 3, pp.72-78.
https://search.emarefa.net/detail/BIM-405024
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 78
Record ID
BIM-405024