The impact of polymerase Chain reaction assays for the detection of hepatitis C virus infection in hemodialysis unit
Joint Authors
Mooij, Jacob M.
Husayn, Majdi M.
Hijazi, Muhammad S.
Bamaga, Muhammad S.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 18, Issue 1 (28 Feb. 2007), pp.107-113, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2007-02-28
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
- Viruses
- Patients
- Hemodialysis
- Complications(Medicine)
- Polymerase chain reaction
- Diagnosis
- Hepatitis C virus
Abstract EN
Hepatitis C virus (HCV) infection is most often diagnosed by detection of antibodies against the virus (HCV Ab).
However, it has been reported that some HCV Ab negative patients test positive for HCV-RNA.
Over a study period of 30 months, all patients on hemodialysis at the Al Hada Armed Forces Hospital in Taif, Saudi Arabia were tested monthly for HCV Ab and twice per year for HCV-RNA.
HCV Ab was tested by a third generation microparticle enzyme immunoassay (MEIA), and HCV-RNA by a qualitative hepatitis-RNA assay, second version (COBAS Amplicor ® PCR), which was recently introduced in the Molecular Pathology Laboratory of our hospital.
Of the 180 patients studied, 34 (18.9 %) had positive HCV Ab, and of the 146 HCV Ab negative patients, five patients tested positive for HCV-RNA (3.42 %).
Our study further finds that, when applying HCV Ab testing only, some patients with HCV viremia may be undetected.
For better HCV infection control, routine HCVRNA testing of dialysis patients should be considered, particularly in areas where the infection is common and in units applying isolation policies.
American Psychological Association (APA)
Husayn, Majdi M.& Mooij, Jacob M.& Hijazi, Muhammad S.& Bamaga, Muhammad S.. 2007. The impact of polymerase Chain reaction assays for the detection of hepatitis C virus infection in hemodialysis unit. Saudi Journal of Kidney Diseases and Transplantation،Vol. 18, no. 1, pp.107-113.
https://search.emarefa.net/detail/BIM-40544
Modern Language Association (MLA)
Husayn, Majdi M.…[et al.]. The impact of polymerase Chain reaction assays for the detection of hepatitis C virus infection in hemodialysis unit. Saudi Journal of Kidney Diseases and Transplantation Vol. 18, no. 1 (Dec. 2007), pp.107-113.
https://search.emarefa.net/detail/BIM-40544
American Medical Association (AMA)
Husayn, Majdi M.& Mooij, Jacob M.& Hijazi, Muhammad S.& Bamaga, Muhammad S.. The impact of polymerase Chain reaction assays for the detection of hepatitis C virus infection in hemodialysis unit. Saudi Journal of Kidney Diseases and Transplantation. 2007. Vol. 18, no. 1, pp.107-113.
https://search.emarefa.net/detail/BIM-40544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 111-113
Record ID
BIM-40544