Effect of nioxim on the activity of inhibited AChE
Joint Authors
al-Bayati, Rida Ibrahim
Muslih, Rad K.
Abd al-Husayn, Muhammad S.
Source
Issue
Vol. 2010, Issue 40 (31 Dec. 2010), pp.692-703, 12 p.
Publisher
University of Babylon College of Sciences
Publication Date
2010-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract AR
تم في هذا البحث دراسة تأثير النيو أوكسيم على أنزيم لأستيل كولين أستريز المثبط بواسطة بعض الملركبات الحلقية غير المتجانسة في مصل الدم الإنسان حيث أظهرت النتائج أن المركب يسبب أعادة تنشيط لفعالية الأنزيم كذلك تم في هذه الدراسة اقتراح آلية عمل لمركبات لأوكسيم كمعيد تنشيط لفعالية المثبط تظهر قابلية هذا المركب على مهاجمة معقد الأنزيم–المثبط (عن طريق ذرة الأوكسجين النيوكليوفيلية) و تحرير الأنزيم الحر.
Abstract EN
This study is designed to show the effects of Nioxim on the activity of inhibited AChE by heterocyclic compounds in sera.
The results obtained showed that both Oxime causes decrease in percentage of inhibit ion.
The mechanism of action of the Oxime as reactivators to inhibited AChE activity were suggested which attributed to the ability of this compound to attack the thion group of the inhibited enzyme (enzyme-inhibitor complex) by the nucleophilic oxygen atom and then liberate the free enzyme.
American Psychological Association (APA)
Abd al-Husayn, Muhammad S.& al-Bayati, Rida Ibrahim& Muslih, Rad K.. 2010. Effect of nioxim on the activity of inhibited AChE. National Journal of Chemistry،Vol. 2010, no. 40, pp.692-703.
https://search.emarefa.net/detail/BIM-405664
Modern Language Association (MLA)
Abd al-Husayn, Muhammad S.…[et al.]. Effect of nioxim on the activity of inhibited AChE. National Journal of Chemistry No. 40 (2010), pp.692-703.
https://search.emarefa.net/detail/BIM-405664
American Medical Association (AMA)
Abd al-Husayn, Muhammad S.& al-Bayati, Rida Ibrahim& Muslih, Rad K.. Effect of nioxim on the activity of inhibited AChE. National Journal of Chemistry. 2010. Vol. 2010, no. 40, pp.692-703.
https://search.emarefa.net/detail/BIM-405664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 703
Record ID
BIM-405664
