Evaluation of serum cholinesterase activity, lipid peroxidation and lipids profile in type 2 diabetes mellitus

Abstract EN

The study was designed to evaluate serum cholinesterase activity, lipid peroxidation, lipids profile and nitric oxide production, in sera of diabetes type 2 and the control group to show whether there are changes in their levels.

The results of this study showed significant elevations (P < 0.001) in each of serum cholinesterase and lipid peroxidation end product represented by serum MDA concentrations in type 2 diabetic patients as compared to control group.

Although, this study showed a non-significant elevation in serum nitrite, the nitrate was elevated significantly (P < 0.001) in diabetic type 2 patients as compared to control group.

The lipids profile of diabetic type 2 patients showed significant changes represented by significant elevations (P < 0.001) in each of TG, t.

cholesterol, LDL and VLDL, and a significant decrease (P < 0.001) in HDL as compared to control group.

Using regression analysis showed a significant positive correlation between serum cholinesterase (P < 0.001) and each of FBS (r = 0.698), MDA (r = 0.69), NOx (r = 0.51), t.

cholesterol (r = 0.487), TG (r = 0.691), LDL (r = 0.575), and VLDL (r = 0.455), and a significant negative correlation (P < 0.001) with HDL (r = -0.861).

Conclusion can be made that diabetes mellitus is a low grade systematic inflammation associated with high oxidative stress, lipid peroxidation and serum cholinesterase activity, which may in turn, affect lipoproteins metabolism.