The influence of serum 25-hydroxy vitamin D levels on helicobacter pylori infection in patients with end-stage renal failure on regular hemodialysis

Abstract EN

This study was designed to determine whether the serum levels of 25-OH vitamin D influence the occurrence of infection with Helicobacter Pylori (H.

Pylori) in patients on maintenance hemodialysis (HD).

The study subjects were patients with end-stage renal disease who were undergoing maintenance dialysis at the hemodialysis section, Hajar Medical, Educational and Therapeutic Center, Shahrekord, Iran.

The serum 25-OH vitamin D level and serum H.

Pylori specific IgG antibody titers were measured using an enzyme-linked immunosorbent assay (ELISA) method.

A total of 36 patients were studied including 21 males and 15 females.

The mean age of the study group was 47 (± 17) years.

The mean level of serum 25-OH vitamin D was 0.5 ± 18.7 nmol / L (median : 3.5) while the mean value of serum H.

Pylori specific IgG antibody titer was 7.7 (± 9.9) u / ml (median : 2 u / ml).

Thus, a significant positive correlation was found between the levels of serum 25-OH vitamin D and serum H.

Pylori specific IgG antibody titers (data adjusted for age, urea reduction rate, duration and dose of dialysis) ( r = 0.36, p = 0.043).

Our study suggests that vitamin D may positively affect the chronic inflammatory status of dialysis patients and may potentiate the immune response in such patients.

Because of this immuno-modulatory effect, vitamin D analogs may offer new means to control the inflammatory status in patients on maintenance dialysis.