Synthesis of [n-ampicilline amic acids] as drug polymers
Joint Authors
al-Salami, Firyal M. A.
al-Sharify, Abbas N. M.
Kazim, Khudayr Jawad
Source
Iraqi National Journal of Chemistry
Issue
Vol. 2011, Issue 44 (31 Dec. 2011), pp.590-601, 12 p.
Publisher
University of Babylon College of Sciences
Publication Date
2011-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
Abstract AR
حضر في هذا البحث المونومرات –Nامبيسيلين حامض المالي اميك M1 و –Nامبيسيلين حامض الستراكونيك M2.
من تفاعل الامبيسيلين مع حامض الماليئك او الستراكونيك اللامائي و بدرجة حرارة الغرفة باستخدام الدايوكسان مذيبا.
بلمر المونيمران المحضران M1 و M2 بالجذور الحرة باستخدام ازوبيس ايسوبيتيرونايتريل AIBN بادئا، إلى البوليمرات المقابلة P1 و P2، ثم حولت إلى املاح الصوديوم للبوليمرات المحضرة P3 و P4 لتسهيل قابلية الإذابة بالماء.
درست الصفات الفيزيائية للمونمرين المحضرين و البوليمرات المقابلة، شخصت بواسطة استخدام أطياف الأشعة تحت الحمراء و الأشعة فوق البنفسجية و قيست اللزوجة الجوهرية باستخدام استوالد فسكوميتر بدرجة 30م∘ و استخدام DMF مذيبا، و قيست كذلك درجة الانتفاخ، و قيست سرع التحرر الدوائي للامبيسيلين و كانت في الوسط القاعدي أعلى من الوسط الحامضي، درست التحاليل DSC, DTA, TG للبوليمرين P1, P2.
Abstract EN
In this paper two monomers have been prepared such as [N-Ampicilline male amic acid M1, and N-Ampicilline citraconic amic acid M2], from reaction of ampicillin with maleic anhydride or citraconic anhydride at room temperature using dioxane as a solvent.
The two new prepared monomers M1andM2 were polymerized by free radical with Azobisisobutyronitrile (AIBN) to their corresponding poly amic acids P1 and P2.
Which were converted to their sodium salt polymers P3 and P4 to enhanced their solubility in water.
The physical and chemical properties were studied, the prepared monomers and polymers were characterized by FTIR and UV.
Spectroscopy, the intrinsic viscosity was measured Ostwald viscometer at 30 °C with DMF as a solvent, the swelling % was calculated and the drug release rate was studied.
Experimental results showed that the hydrolysis of ampicilline in alkaline medium was higher than acidic medium.
TG and DTA and DSC Analysis were studied for P1 and P2.
American Psychological Association (APA)
al-Salami, Firyal M. A.& al-Sharify, Abbas N. M.& Kazim, Khudayr Jawad. 2011. Synthesis of [n-ampicilline amic acids] as drug polymers. Iraqi National Journal of Chemistry،Vol. 2011, no. 44, pp.590-601.
https://search.emarefa.net/detail/BIM-406800
Modern Language Association (MLA)
al-Salami, Firyal M. A.…[et al.]. Synthesis of [n-ampicilline amic acids] as drug polymers. Iraqi National Journal of Chemistry No. 44 (2011), pp.590-601.
https://search.emarefa.net/detail/BIM-406800
American Medical Association (AMA)
al-Salami, Firyal M. A.& al-Sharify, Abbas N. M.& Kazim, Khudayr Jawad. Synthesis of [n-ampicilline amic acids] as drug polymers. Iraqi National Journal of Chemistry. 2011. Vol. 2011, no. 44, pp.590-601.
https://search.emarefa.net/detail/BIM-406800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 601
Record ID
BIM-406800
