Successful prevention of tunneled central catheter infection by antibiotic lock therapy using vancomycin and gentamycin
Joint Authors
al-Huwaysh, Abd Allah K.
Abd al-Rahman, Ibrahim Said
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 18, Issue 2 (30 Apr. 2007), pp.239-247, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2007-04-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Tunneled, cuffed central vein catheters (TCC) are widely used for delivering hemodialysis (HD).
Among the complications associated with central vein catheters in HD patients, infection is the principal cause of morbidity and mortality.
The optimal strategy for management of TCC infections is unclear.
This prospective study was aimed at assessing the efficacy of antibiotic-lock therapy using vancomycin and gentamycin in preventing catheterrelated blood stream bacterial infection in patients on HD.
A total of 63 HD patients with 81 TCC were enrolled at the time of catheter insertion.
Patients were randomized into two groups : Group I (33 patients, 37 insertions) included TCC with antibiotic lock therapy, and Group II (30 patients, 44 insertions) with routine TCC management.
Infection-free catheter survival of both groups was evaluated and compared at the end of the 12-month study period.
A total of 57 TCC infections were encountered with an incidence rate of 8.95 infections per 1000 dialysis sessions (DS).
The rate of infection was significantly lower in Group I (4.54 per 1000 DS) as compared to Group II (13.11 per 1000 DS), p < 0.001.
The incidence rates of bacteremia as well as clinical sepsis were also significantly lower in Group I than in Group II (p < 0.001).
There was no statistically significant difference between the rates of access site infection in the two Groups (p > 0.05).
Our study suggests that antibiotic-lock therapy using a combination of vancomycin and gentamycin is useful in preventing catheter-related blood stream infection in patients on HD.
American Psychological Association (APA)
al-Huwaysh, Abd Allah K.& Abd al-Rahman, Ibrahim Said. 2007. Successful prevention of tunneled central catheter infection by antibiotic lock therapy using vancomycin and gentamycin. Saudi Journal of Kidney Diseases and Transplantation،Vol. 18, no. 2, pp.239-247.
https://search.emarefa.net/detail/BIM-40691
Modern Language Association (MLA)
al-Huwaysh, Abd Allah K.& Abd al-Rahman, Ibrahim Said. Successful prevention of tunneled central catheter infection by antibiotic lock therapy using vancomycin and gentamycin. Saudi Journal of Kidney Diseases and Transplantation Vol. 18, no. 2 (Dec. 2007), pp.239-247.
https://search.emarefa.net/detail/BIM-40691
American Medical Association (AMA)
al-Huwaysh, Abd Allah K.& Abd al-Rahman, Ibrahim Said. Successful prevention of tunneled central catheter infection by antibiotic lock therapy using vancomycin and gentamycin. Saudi Journal of Kidney Diseases and Transplantation. 2007. Vol. 18, no. 2, pp.239-247.
https://search.emarefa.net/detail/BIM-40691
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 245-247
Record ID
BIM-40691