Synthesis and study of acetylenic amines derivatives from p-aminophenol

Abstract EN

New acetylenic amines derivatives from p-aminophenol have been synthesized through Mannich reaction which involved reaction of p-acetamidophenyl propargyl ether and p-phthalimidophenyl propargyl ether with paraformaldehyde and secondary amines.

Some of the synthesized acetylenic amines passed through alkaline hydrolysis to release free amine group which was allowed to be reacted with aldehyde or ketone to produce shiff bases.

The synthesized compounds were investigated by physical and spectroscopic methods.