Interferon-Beta for glomerulonephritis?
Author
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 18, Issue 3 (31 Dec. 2007), pp.333-336, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2007-12-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Interferon beta (IFNβ) is used in the therapy of multiple sclerosis (MS), which develops from the activation of autoreactive T lymphocytes against peptides of myelin basic protein.
IFNβ was demonstrated to have beneficial effects in experimental models of glomerulonephritis (GN), such as decreasing proteinuria via Il-10 release.
T helper (Th-1) lymphocyte responses are reduced, the actions of metalloproteinase (MMP9) are suppressed, and the functions of regulatory T cells are promoted.
In concept, IFNI3 therapy might be beneficial in patients with life threatening forms of GN, such as Goodpasture's syndrome or vasculitis.
Further research is warranted to study the effect of IFNβ on GN in clinical settings.
American Psychological Association (APA)
Nigel Wardle, E.. 2007. Interferon-Beta for glomerulonephritis?. Saudi Journal of Kidney Diseases and Transplantation،Vol. 18, no. 3, pp.333-336.
https://search.emarefa.net/detail/BIM-40820
Modern Language Association (MLA)
Nigel Wardle, E.. Interferon-Beta for glomerulonephritis?. Saudi Journal of Kidney Diseases and Transplantation Vol. 18, no. 3 (Dec. 2007), pp.333-336.
https://search.emarefa.net/detail/BIM-40820
American Medical Association (AMA)
Nigel Wardle, E.. Interferon-Beta for glomerulonephritis?. Saudi Journal of Kidney Diseases and Transplantation. 2007. Vol. 18, no. 3, pp.333-336.
https://search.emarefa.net/detail/BIM-40820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 335-336
Record ID
BIM-40820