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Anti-inflammatory activity of stachys pilifera benth
Joint Authors
Sidqi, Hibah Allah
Zarezade, Vahid
Sidiqi, Husayn
Turi, Mahdi Akbartabar
Barmak, Mehrzad Jafari
Uzayzi, Arsalan
Ghavamizadah, Mahdi
Mustaf zadah, Mustafa
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 9 (30 Sep. 2014), pp.1-8, 8 p.
Publisher
Publication Date
2014-09-30
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background : Stachys piliferaBenth has long been used to treat infectious diseases as well as respiratory and rheumatoid disorders in Iranian folk medicine.
Antioxidants, antitumor, and antimicrobial properties of the plant have been reported. Objectives : This experimental study was designed to evaluate systemic and topical anti-inflammatory effects of the hydro-alcoholic extract from aerial parts of Stachys pilifera (HESP). Materials and Methods: Anti-inflammatory effects of HESP was studied in four well-known animal models of inflammation, including carrageenan- or formalin-induced paw edema in rat (thirteen groups, 6 rats per each group), and 12-O-tetradecanoylphorbol-13-acetate (TPA)- or xylene-induced ear edema in mouse (ten groups, 6 mice per each group).
The rats received HESP (50-400 mg/ kg) orally 45 minutes before the subplantar injection of carrageenan or formalin.
In TPA or xylene tests, HESP (1, 2.5, and 5 mg/ear) was applied topically simultaneous with these phlogistic agents on the ear mice.
Finally, pathological examination of the inflamed tissues (paw and ear) was carried out. Results : Acute toxicity study of the extract showed that no rats were killed at 5000 mg / kg (LD50 > 5000 mg / kg).
The extract (100 and 200 mg / kg) significantly suppressed carrageenan-induced paw edema 1, 2, 3, and 4 hours after carrageenan challenge in comparison with the control group (P < 0.001).
The HESP (100 and 200 mg / kg) also produced a considerable antiedematogenic effect in the formalin test over a period of 24 hours (P < 0.01).
Furthermore, topical administration of the HESP (1, 2.5, and 5 mg / ear) inhibited TPA- and xylene-induced ear edema in comparison with the control group (P < 0.001).
The pathological analysis of the paws and ears revealed that HESP was capable of reducing tissue destruction, cellular infiltration, and subcutaneous edema induced by the indicated phlogistic agents. Conclusions : The present data confirmed systemic and topical anti-inflammatory effects of Stachys pilifera which is comparable to indomethacin.
American Psychological Association (APA)
Sidqi, Hibah Allah& Zarezade, Vahid& Sidiqi, Husayn& Turi, Mahdi Akbartabar& Barmak, Mehrzad Jafari& Uzayzi, Arsalan…[et al.]. 2014. Anti-inflammatory activity of stachys pilifera benth. Iranian Red Crescent Medical Journal،Vol. 16, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-408203
Modern Language Association (MLA)
Sidqi, Hibah Allah…[et al.]. Anti-inflammatory activity of stachys pilifera benth. Iranian Red Crescent Medical Journal Vol. 16, no. 9 (Sep. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-408203
American Medical Association (AMA)
Sidqi, Hibah Allah& Zarezade, Vahid& Sidiqi, Husayn& Turi, Mahdi Akbartabar& Barmak, Mehrzad Jafari& Uzayzi, Arsalan…[et al.]. Anti-inflammatory activity of stachys pilifera benth. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 9, pp.1-8.
https://search.emarefa.net/detail/BIM-408203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-408203