Hepatotoxicity of halogenated inhalational anesthetics
Joint Authors
Safari, Said
Motavaf, Mahsa
Siamdoust, Sayyid Alirida Sayyid
Alavian, Sayyid Muayyad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 9 (30 Sep. 2014), pp.1-5, 5 p.
Publisher
Publication Date
2014-09-30
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Topics
Abstract EN
Context : Halogenated inhalational anesthetics are currently the most common drugs used for the induction and maintenance of general anesthesia.
Postoperative hepatic injury has been reported after exposure to these agents.
Based on much evidence, mechanism of liver toxicity is more likely to be immunoallergic.
The objective of this review study was to assess available studies on hepatotoxicity of these anesthetics. Evidence Acquisition : We searched PubMed, Google Scholar, Scopus, Index Copernicus, EBSCO and the Cochrane Database using the following keywords: “inhalational Anesthetics” and “liver injury”; “inhalational anesthetics” and “hepatotoxicity”; “volatile anesthetics” and “liver injury” ; “volatile anesthetics” and hepatotoxicity for the period of 1966 to 2013.
Fifty two studies were included in this work. Results : All halogenated inhalational anesthetics are associated with liver injury.
Halothane, enflurane, isoflurane and desflurane are metabolized through the metabolic pathway involving cytochrome P-450 2E1 (CYP2E1) and produce trifluoroacetylated components; some of which may be immunogenic.
The severity of hepatotoxicity is associated with the degree by which they undergo hepatic metabolism by this cytochrome.
However, liver toxicity is highly unlikely from sevoflurane as is not metabolized to trifluoroacetyl compounds. Conclusions : Hepatotoxicity of halogenated inhalational anesthetics has been well documented in available literature.
Halothane-induced liver injury was extensively acknowledged ; however, the next generation halogenated anesthetics have different molecular structures and associated with less hepatotoxicity.
Although anesthesia-induced hepatitis is not a common occurrence, we must consider the association between this disorder and the use of halogenated anesthetics.
American Psychological Association (APA)
Safari, Said& Motavaf, Mahsa& Siamdoust, Sayyid Alirida Sayyid& Alavian, Sayyid Muayyad. 2014. Hepatotoxicity of halogenated inhalational anesthetics. Iranian Red Crescent Medical Journal،Vol. 16, no. 9, pp.1-5.
https://search.emarefa.net/detail/BIM-408217
Modern Language Association (MLA)
Safari, Said…[et al.]. Hepatotoxicity of halogenated inhalational anesthetics. Iranian Red Crescent Medical Journal Vol. 16, no. 9 (Sep. 2014), pp.1-5.
https://search.emarefa.net/detail/BIM-408217
American Medical Association (AMA)
Safari, Said& Motavaf, Mahsa& Siamdoust, Sayyid Alirida Sayyid& Alavian, Sayyid Muayyad. Hepatotoxicity of halogenated inhalational anesthetics. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 9, pp.1-5.
https://search.emarefa.net/detail/BIM-408217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-408217