Comparison of the use of tropisetron and metoclopromid in the prevention of post-operative nausea and vomiting

Abstract EN

Post–operative nausea and vomiting remain among the most common and distressing symptoms occurring after surgery under general anesthesia.

In the current study we compare the prophylactic antiemetic effect of Tropisetron, Metoclopromid, and placebo.

All are given as identical oral capsules 2 hours pre-operatively.

90 patients undergoing major surgery were divided in to 3groups each group contain 30 patient (15 male and 15 female) and were observed for at least 24 hours after operation.

The study revealed that nausea and vomiting occurred was reduced in Tropisetron treated patients than placebo treated patients.

And the percentage of nausea and vomiting of Tropisetron treated patients was reduced to 30% while in Metoclopromid treated patients reduced to 43.3 % and placebo was 60 %.

We conclude that post-operative nausea and vomiting were reduced when Tropisetron given prophelacticaly than Metoclopromid and placebo.