Effect of sildenafil citrate (Viagra) on the lipid profile of the normal and experimentally induced diabetic male rats
Joint Authors
al-Fartusi, Khalid G.
al-Salih, Raid M. H.
Husayn, Murtada Hafiz
Source
Issue
Vol. 4, Issue 2 (31 May. 2014), pp.72-78, 7 p.
Publisher
University of Thi-Qar College of Science
Publication Date
2014-05-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
The current study was designed to determine effectiveness of sildenafil citrate (viagra) on lipid profile of normal and experimentally induced diabetic male rats, the current study was carried out on (36) mature male mature rats, they were divided randomly into six equal groups, 6 of each group.
The first group was administrated orally with (0.2 ml) of normal physiological saline (0.9 % Nacl), the second group was injected (IP) by (0.5 ml / animal) with alloxane (125 mg.kg-1), the third and fourth groups were administrated orally with viagra at doses (4 and 8 mg.kg-1), respectively, while the fifth and sixth groups injected (0.5 ml / animal) with alloxane (125 mg.kg-1), after one week, the (fifth and sixth) group were administrated orally with viagra at doses (4 and 8 mg.kg-1), respectively.
The experiment was continued for 21 days.
At the end of the experimental period, the animals were sacrificed, the blood samples were collected and the serum concentration of total cholesterol (T.
C.), triglycerides (T.
G.), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and atherogenic index were determined in the serum.
The results showed a significant increase in the serum level of T.
C., T.
G., LDL, VLDL and atherogenic index to the normal and diabetic rats treated with viagra and decrease in HDL concentration of the normal and diabetic rats administered with viagra when compared this two groups with control and diabetic groups respectively.
American Psychological Association (APA)
al-Fartusi, Khalid G.& al-Salih, Raid M. H.& Husayn, Murtada Hafiz. 2014. Effect of sildenafil citrate (Viagra) on the lipid profile of the normal and experimentally induced diabetic male rats. Journal of Thi-Qar Science،Vol. 4, no. 2, pp.72-78.
https://search.emarefa.net/detail/BIM-408642
Modern Language Association (MLA)
Husayn, Murtada Hafiz…[et al.]. Effect of sildenafil citrate (Viagra) on the lipid profile of the normal and experimentally induced diabetic male rats. Journal of Thi-Qar Science Vol. 4, no. 2 (May. 2014), pp.72-78.
https://search.emarefa.net/detail/BIM-408642
American Medical Association (AMA)
al-Fartusi, Khalid G.& al-Salih, Raid M. H.& Husayn, Murtada Hafiz. Effect of sildenafil citrate (Viagra) on the lipid profile of the normal and experimentally induced diabetic male rats. Journal of Thi-Qar Science. 2014. Vol. 4, no. 2, pp.72-78.
https://search.emarefa.net/detail/BIM-408642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 76-78
Record ID
BIM-408642