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Benzhexol causes conditioning place preference in male rats
Other Title(s)
عقار البنزهكسول يسبب تفضيلا شرطيا للمكان في ذكور الجرذان
Joint Authors
Abd al-Latif, Abd al-Razzaq
Salman, Salman Muhammad
Ali, Husam Hassun
Source
Issue
Vol. 11, Issue 3 (30 Sep. 2014), pp.487-492, 6 p.
Publisher
University of Babylon College of Medicine
Publication Date
2014-09-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract AR
يعتبر البنزهكسول هايدروكلورايد (الارتين) دواء فعالا مضادا للكولينرجك, و ان اساءة استعمال هذا الدواء زاد بشكل مضطرد في السنوات الاخيرة.
هدف البحث هو لبيان تفضيل المكان الشرطي لعقار البنزهكسول في ذكور الجرذان باستعمال اختبار تفضيل المكان الشرطي.
تم استعمل ستة عشر جرذا ذكرا, قسمت ال مجموعتين بواقع ثمانية حيوانات في كل مجموعة و قد وضع كل جرذ من المجموعة الاولى في قسم السيطرة و في حال دخوله قسم الدواء يعطى الحيوان حجما من النورمال سلاين مساويا لجرعة البنزهكسول, مرتين يوميا عن طريق الفم بواسطة انبوبة المعدة.
و قد تم وضع كل جرذ من المجموعة الثانية في قسم السيطرة و في حال دخوله قسم الدواء يعطى الحيوان 0.2 ملغم / كغم من البنزهكسول, مرتين يوميا عن طريق الفم بواسطة انبوبة المعدة.
كررت الخطوتين السابقتين مرتين يوميا لمدة عشرة ايام.
في اليوم الحادي عشر من الدراسة ان الوقت الذي قضته حيوانات المجموعة الثانية في قسم الدواء قد ازداد زيادة ذو قيمه (0.05
Abstract EN
Background : Benzhexol hydrochloride (Trihexyphenidyl ) is a potent anticholinergic agent.
Abuse of benzhexol has been noted with increasing frequency in recent years Aim of the study : To determine the conditioning place preference of benzhexol administration in the male rats.
Materials and methods : Sixteen male, adult, albino rats were useded in this experiments.
The animals were randomly divided into 2 groups, eight rats for each group.
Each rat of group 1 was placed in the control compartment and once the rat enter the drug compartment, the animal received N.
S.
in equal volume to the benzhexol dose,, orally (p.
o.), by gastric tube.
Each rat of group 2 was placed in the control compartment and once the rat enter the drug compartment, the animal received benzhexol 0.2 mg / kg, p.
o., by gastric tube.
Previous two steps were repeated twice daily for 10 days.
On 11th day, each rat in was placed in the control compartment for 10 minutes and all behaviors of the animals were recorded by video camera.
Results and conclusion : In group 2 (benzhexol 0.2 mg / kg), the time which spent in the drug chamber (white and brown color) significantly increased (P < 0.05) as compared with the time which spent in the control chamber.
This study reported that administration of 0.2 mg / kg of benzhexol, twice daily (pd), for 10 days caused conditioning place preference in the rats.
American Psychological Association (APA)
Salman, Salman Muhammad& Abd al-Latif, Abd al-Razzaq& Ali, Husam Hassun. 2014. Benzhexol causes conditioning place preference in male rats. Medical Journal of Babylon،Vol. 11, no. 3, pp.487-492.
https://search.emarefa.net/detail/BIM-409565
Modern Language Association (MLA)
Ali, Husam Hassun…[et al.]. Benzhexol causes conditioning place preference in male rats. Medical Journal of Babylon Vol. 11, no. 3 (2014), pp.487-492.
https://search.emarefa.net/detail/BIM-409565
American Medical Association (AMA)
Salman, Salman Muhammad& Abd al-Latif, Abd al-Razzaq& Ali, Husam Hassun. Benzhexol causes conditioning place preference in male rats. Medical Journal of Babylon. 2014. Vol. 11, no. 3, pp.487-492.
https://search.emarefa.net/detail/BIM-409565
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 491-492
Record ID
BIM-409565