Potentiometric study for determination of PKa values for schiff bases derived from 2-acetyl pyridine with heterocyclic amines

Abstract EN

The project was started by synthesis of two Schiff bases from 2- acetyl pyridine with 4-amino pyrimidine and 4-amino pyridine by a standard method.

The structures of these Schiff bases had confirmed by physical method, namely by using U.V-IR spectra and melting points.

The main aims of the study was the determination of two consecutive nitrilium ions ionization constants pK1 and pK2 for in each molecule simultaneously.

The last was regarded an improvement in potentiometric method for determination of pKa in these molecules.

Finaly factors govern, the pK1 or pK2 values in these Schiff base, as structure of imines, temperature and mixed solvent of ethanol in the range (10-60) % in water were given and discussed.