Nephrotic proteinuria and the automatic nervous system

Abstract EN

Nephrotic proteinuria triggers off complex neuro-endocrine mechanisms where forebrain activation results in sympathetic over activity.

An attempt is made to discuss and analyze the renal sympathetic efferent nerve hyperactivity, the role played by the angiotensin / nitric oxide system during proteinuria and the nitric oxide / angiotensin imbalance in the hypothalamus.

Several questions arise : further experimental and clinical studies are necessary.

The answers to these questions may disclose new clinical and therapeutic perspectives for the nephrotic syndrome.